Chlorfortunone A
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity.
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- 分子式: C31H38O5
- 分子量:490.63
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:10, 20, 40 μM
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Incubation Time:4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
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Result:Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.
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Cell Line:MDA-MB-231 cells
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Concentration:25 μM
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Incubation Time:48 hours
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Result:Significantly downregulated the expression of vimentin.
化学情報
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分子量 490.63
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分子式 C31H38O5
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SMILES
C[C@@]1([C@@H]2C[C@@H]2C(CC3)=C1[C@]([C@]3(C=C4)C=C[C@@]4([C@@H](C(C)C)C5)[C@@H](C5=O)C)([H])/C6=C(C)/C(OC)=O)[C@@H](O)C6=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Chlorfortunone A 関連分類
HY-N10577 関連分類
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