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製品番号: HY-101521

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CHMFL-BTK-01

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation.

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CAS 番号: 2095280-64-9
分子式: C₃₈H₄₁N₅O₅
分子量:647.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CHMFL-BTK-01 構造式

CAS 番号: 2095280-64-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation^[1].

IC₅₀ & Target

IC50: 7 nM (BTK)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	GI₅₀	2.1 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human MV411 cells Growth inhibition of human MV411 cells	[PMID: 28315597]
NB-4	GI₅₀	6.6 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human NB4 cells Growth inhibition of human NB4 cells	[PMID: 28315597]
OCI-AML-3	GI₅₀	3.8 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human OCI-AML3 cells Growth inhibition of human OCI-AML3 cells	[PMID: 28315597]
Pfeiffer	GI₅₀	4.5 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human Pfeiffer cells Growth inhibition of human Pfeiffer cells	[PMID: 28315597]
Ramos	GI₅₀	3.5 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human Ramos cells Growth inhibition of human Ramos cells	[PMID: 28315597]
SKM-1	GI₅₀	7.1 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human SKM1 cells Growth inhibition of human SKM1 cells	[PMID: 28315597]
SU-DHL-2	GI₅₀	3 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human SU-DHL-2 cells Growth inhibition of human SU-DHL-2 cells	[PMID: 28315597]
U2932	GI₅₀	2.4 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human U2932 cells Growth inhibition of human U2932 cells	[PMID: 28315597]
U-937	GI₅₀	4.8 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human U937 cells Growth inhibition of human U937 cells	[PMID: 28315597]

化学情報

CAS 番号 2095280-64-9
分子量 647.76
分子式 C₃₈H₄₁N₅O₅
SMILES

O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liang Q, et al. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inh [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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