CRTh2 antagonist 2
Based on 1 Customer Validation
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.78%
- CAS 番号: 780763-95-3
- 分子式: C26H23ClN4O3
- 分子量:474.94
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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DP |
CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 780763-95-3
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性状 Solid
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分子量 474.94
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分子式 C26H23ClN4O3
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Color Off-white to light yellow
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SMILES
O=C(O)CC1=C(N(C)C)N=C(CC2=CC=C(NC(C3=CC=C4C=CC=CC4=C3)=O)C=C2)N=C1Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (263.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1055 mL | 10.5276 mL | 21.0553 mL | 52.6382 mL |
| 5 mM | 0.4211 mL | 2.1055 mL | 4.2111 mL | 10.5276 mL | |
| 10 mM | 0.2106 mL | 1.0528 mL | 2.1055 mL | 5.2638 mL | |
| 15 mM | 0.1404 mL | 0.7018 mL | 1.4037 mL | 3.5092 mL | |
| 20 mM | 0.1053 mL | 0.5264 mL | 1.0528 mL | 2.6319 mL | |
| 25 mM | 0.0842 mL | 0.4211 mL | 0.8422 mL | 2.1055 mL | |
| 30 mM | 0.0702 mL | 0.3509 mL | 0.7018 mL | 1.7546 mL | |
| 40 mM | 0.0526 mL | 0.2632 mL | 0.5264 mL | 1.3160 mL | |
| 50 mM | 0.0421 mL | 0.2106 mL | 0.4211 mL | 1.0528 mL | |
| 60 mM | 0.0351 mL | 0.1755 mL | 0.3509 mL | 0.8773 mL | |
| 80 mM | 0.0263 mL | 0.1316 mL | 0.2632 mL | 0.6580 mL | |
| 100 mM | 0.0211 mL | 0.1053 mL | 0.2106 mL | 0.5264 mL |
CRTh2 antagonist 2 関連分類
HY-125970 関連分類
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