DENV-IN-4
DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect.
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- CAS 番号: 2762302-75-8
- 分子式: C28H32N4O4Si
- 分子量:516.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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RNA Polymerase |
DENV-IN-4 (compound 15) (0.064-200 μM; 3 days) has antiviral effect and not related to its toxicity (DENV EC50=4.79 μM, Vero CC50>100, SI>20.9)[1].
DENV-IN-4 (3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7; 48 hours) inhibits the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero[1].
DENV-IN-4 (7.5 and 15 μM; 48 hours) can effectively inhibit DENV infection in Vero cells, and completely inhibited at 15 μM[1].
DENV-IN-4 (0-15 μM; 48 hours) inhibits DENV2 E protein production with good concentration-dependent relationship in Vero cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero[1]
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Concentration:0.064-200 μM
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Incubation Time:3 days
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Result:Showed antiviral effect of DENV-IN-4 was not related to its toxicity (Vero EC50=4.79 μM, CC50>100, SI>20.9).
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Cell Line:Vero, A549 and Huh-7 cells[1]
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Concentration:3.125-50 μM in Vero, 3.75-30 μM in A549 and Huh-7
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Incubation Time:48 hours
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Result:Inhibited the expression level of DENV2 with concentration-dependence, and inhibition curves were smoother in Vero.
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Cell Line:Vero[1]
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Concentration:7.5 and 15 μM
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Incubation Time:48 hours
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Result:Effectively inhibited DENV infection and completely inhibited at 15 μM.
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Cell Line:Vero[1]
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Concentration:0-15 μM
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Incubation Time:48 hours
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Result:Inhibited DENV2 E protein production with good concentration-dependent relationship.
化学情報
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CAS 番号 2762302-75-8
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分子量 516.66
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分子式 C28H32N4O4Si
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SMILES
O=C1[C@@](CC2=CC=CC=C23)([H])N3[C@](C4=CC=C(C=C4)O[Si](C)(C)C(C)(C)C)([H])N1NC5=CC=C(C=C5)[N+]([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DENV-IN-4 関連分類
HY-115929 関連分類
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