Estrogen receptor modulator 12
Estrogen receptor modulator 12 (compound 1a-(R)) is a selective estrogen receptor modulator with estrogen agonist and antagonist activities in in vivo models. Estrogen receptor modulator 12 exhibits antagonist effects on the uterus and estrogen agonist activities on bone, plasma lipids, hot flashes, and vagina in in vivo models, and is a potential compound for suppressing postmenopausal symptoms.
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- CAS 番号: 554431-74-2
- 分子式: C30H31NO5
- 分子量:485.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Ishikawa | IC50 |
0.2 nM
Compound: 1a-(R), JNJ-17148066
|
Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay
Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay
|
[PMID: 19366247] |
| MCF7 | IC50 |
11 nM
Compound: 1a-(R), JNJ-17148066
|
Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine incorporation assay
Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine incorporation assay
|
[PMID: 19366247] |
化学情報
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CAS 番号 554431-74-2
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分子量 485.57
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分子式 C30H31NO5
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SMILES
OC1=CC=C(C([C@@H](C2=CC=C(C=C2)OCCN3CCCCC3)OC4=C5)=C(CCO6)C4=CC=C5O)C6=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)