Cyp7a1 - cytochrome P450 family 7 subfamily A member 1 Gene

Also Known as CHAP; CYP7; CYP7S1

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 25428

Summary

Enables Cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including bile acid biosynthetic process; cellular response to cholesterol; and regulation of lipid biosynthetic process. Located in intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and non-alcoholic steatohepatitis. Orthologous to human CYP7A1 (Cytochrome P450 family 7 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp7a1 Products (1)

mRNA Protein Name
NM_012942.2 NP_037074.1 cytochrome P450 7A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables cholesterol 7-alpha-monooxygenase activity IDA
IDA: Inferred from direct assay
1694852 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in bile acid and bile salt transport IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in bile acid biosynthetic process IDA
IDA: Inferred from direct assay
1694852 RGD
involved in cellular response to cholesterol IDA
IDA: Inferred from direct assay
1694852 RGD
involved in cholesterol catabolic process IDA
IDA: Inferred from direct assay
1694852 RGD
involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
1694852 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
15521018 RGD
involved in negative regulation of fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
23536474 RGD
involved in positive regulation of cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
23536474 RGD
involved in regulation of bile acid biosynthetic process IDA
IDA: Inferred from direct assay
1694852 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
1694852 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 7A1

  • 24-hydroxycholesterol 7-alpha-hydroxylase

  • CYPVII

  • cholesterol 7-alpha-hydroxylase

  • cholesterol 7-alpha-monooxygenase

  • cytochrome P450 (cholesterol hydroxylase 7 alpha)

  • cytochrome P450, 7a1

  • cytochrome P450, family 7, subfamily a, polypeptide 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-106539 Colesevelam hydrochloride 98.00% Unkown

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-19264 264W94 / Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-W008226 Phloracetophenone 99.96% Unkown
HY-113259 7α-Hydroxy-4-cholesten-3-one 99.60% Unkown
HY-163436 F44-A13 96.73% Unkown
HY-N0430A Coptisine Sulfate 99.37% Unkown
HY-117147A GSK2945 hydrochloride 98.49% Unkown
HY-117147 GSK2945 Activator / Unkown
HY-175266 MI1013 99.10% Unkown
HY-N0430 Coptisine / Unkown
HY-RS03487 CYP7A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181761 FXR agonist 16 Agonist / Unkown
HY-RS03488 CYP7B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174703 Human FGF19 mRNA / Unkown
HY-N13218 Pueraria Extract / Unkown
HY-RS17211 Cyp7a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18706 Cyp7b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23663 Cyp7a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25193 Cyp7b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Cyp7a1 NCBI NCBI:1581