ANGPTL4 - angiopoietin like 4 Gene

Also Known as NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51129

About ANGPTL4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,364,155-8,374,370 (from NCBI)

This gene has 11 transcripts (splice variants), 240 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues.

Summary

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and Insulin sensitivity. This protein can also act as an Apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

ANGPTL4 Products (2)

mRNA	Protein	Name
NM_001039667.3	NP_001034756.1	angiopoietin-related protein 4 isoform b precursor
NM_139314.3	NP_647475.1	angiopoietin-related protein 4 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables identical protein binding	IPI IPI: Inferred from physical interaction	19028676	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21397862	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10698685	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	19542565	GOA
involved in protein unfolding	IDA IDA: Inferred from direct assay	29899144	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in extracellular region	IDA IDA: Inferred from direct assay	10698685	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10698685	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL4 Protein Structure

Fibrinogen_C

0
100
200
300
406 a.a.

Protein Preferred Names	Protein Names
angiopoietin-related protein 4	PPARG angiopoietin related protein

ANGPTL4 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ANGPTL4	Q9BY76	ITGB5	Homo sapiens	P18084	Anti Bait CoIP	21397862
Intra	ANGPTL4	Q9BY76	NMT2	Homo sapiens	O60551	Anti Tag CoIP	33961781
Intra	ANGPTL4	Q9BY76	LPL	Homo sapiens	P06858	ELISA	19318355
Intra	ANGPTL4	Q9BY76	ANGPTL4	Homo sapiens	Q9BY76	GMS	19028676
Intra	ANGPTL4	Q9BY76	PM20D2	Homo sapiens	Q8IYS1	Anti Tag CoIP	33961781
Intra	ANGPTL4	Q9BY76	AASDHPPT	Homo sapiens	Q9NRN7	Anti Tag CoIP	33961781
Intra	ANGPTL4	Q9BY76	PM20D2	Homo sapiens	Q8IYS1	Anti Tag CoIP	28514442
Intra	ANGPTL4	Q9BY76	AASDHPPT	Homo sapiens	Q9NRN7	Anti Tag CoIP	28514442
Intra	ANGPTL4	Q9BY76	ITGB1	Homo sapiens	P05556	PLA	21397862
Intra	ANGPTL4	Q9BY76	NMT2	Homo sapiens	O60551	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANGPTL4 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7507	ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)	Q9BY76-1(P166-S406)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700562	ANGPTL4/Angiopoietin-related 4 Protein, Human (GST)	Q9BY76-1 (V28-E403)	≥ 90%, as determined by reducing SDS-PAGE.

ANGPTL4 抗体

製品番号	製品名	アプリケーション	反応性
HY-P82345	Angiopoietin Like 4 Antibody (YA2090)	WB, ICC/IF, FC	Human
HY-P82345A	Angiopoietin Like 4 Antibody (YA2090)(PBS only)	WB, ICC/IF, FC	Human

関連疾患

Diseases	Alias
Plasma Triglyceride Level Quantitative Trait Locus	TGQTL Plasma Triglyceride Level Qtl, Low
Gastric Antral Vascular Ectasia	Watermelon Stomach Gave
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Endometrial Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of Endometrium
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Mesenteric Lymphadenitis	Mesenteric Adenitis
Hypobetalipoproteinemia, Familial, 2	Familial Hypobetalipoproteinemia 2 FHBL2 Hypolipidemia, Familial, Combined Combined Familial Hypolipidemia Combined Hypobetalipoproteinemia Familial Hypobetalipoproteinemia, Familial, Type 2
Familial Lipoprotein Lipase Deficiency	Familial Lpl Deficiency Familial Hyperchylomicronemia Hyperlipoproteinemia Type I Familial Hyperlipoproteinemia Type I Hyperchylomicronemia Burger-Grutz Syndrome Endogenous Hypertriglyceridaemia Familial Fat-Induced Hypertriglyceridemia Lipd Deficiency Lpl Deficiency Lipase D Deficiency Lipoprotein Lipase Deficiency, Familial Familial Chylomicronemia Syndrome Fredrickson Type I Hyperlipoproteinemia Fredrickson Type I Lipaemia Hypercholesterinaemic Xanthomatosis Mixed Hyperglyceridemia Lipoprotein Lipase Deficiency Type I Hyperlipoproteinemia Hyperlipoproteinemia Type Ia Familial Hyperlipo-Proteinemia Type 1
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Diabetes Mellitus	Diabetes
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-103325	JTE-907	Activator	98.54%	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P990335	Anti-ANGPTL4 Antibody	Inhibitor	97.18%	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	ANGPTL4	VGNC	VGNC:37860
Mus musculus	ANGPTL4	MGD	MGI:1888999
Rattus norvegicus	ANGPTL4	RGD	RGD:735058
Felis catus	ANGPTL4	VGNC	VGNC:59780
Bos taurus	ANGPTL4	VGNC	VGNC:25893
Macaca mulatta	ANGPTL4	VGNC	VGNC:108464
Others	ANGPTL4	NCBI