MAP2K2 - mitogen-activated protein kinase kinase 2 Gene

Also Known as CFC4; MEK2; MKK2; MAPKK2; PRKMK2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 5605

About MAP2K2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,090,321-4,124,122 (from NCBI)

This gene has 15 transcripts (splice variants), 268 orthologues, 8 paralogues and is associated with 84 phenotypes. Ubiquitous expression in duodenum (RPKM 32.3), testis (RPKM 26.3) and 25 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

MAP2K2 Products (3)

mRNA	Protein	Name
XM_006722799.3	XP_006722862.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X1
XM_047439100.1	XP_047295056.1	dual specificity mitogen-activated protein kinase kinase 2 isoform X2
NM_030662.4	NP_109587.1	dual specificity mitogen-activated protein kinase kinase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	8388392	GOA
enables MAP-kinase scaffold activity	IMP IMP: Inferred from mutant phenotype	29433126	GOA
enables PDZ domain binding	IDA IDA: Inferred from direct assay	21615688	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11909642	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	8388392	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10409742	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24375836	GOA
involved in peptidyl-serine autophosphorylation	IDA IDA: Inferred from direct assay	8388392	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24375836	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24375836	GOA
involved in positive regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8388392	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21615688	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	21615688	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	21615688	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21615688	GOA
located in microtubule	IDA IDA: Inferred from direct assay	21615688	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21615688	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2K2 Protein Structure

Pkinase

0
100
200
300
400 a.a.

Protein Preferred Names	Protein Names
dual specificity mitogen-activated protein kinase kinase 2	ERK activator kinase 2 MAP kinase kinase 2 MAPK/ERK kinase 2 mitogen-activated protein kinase kinase 2, p45

MAP2K2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MAP2K2	P36507	DLG1	Homo sapiens	Q12959	IF	21615688
Intra	MAP2K2	P36507	DLG1	Homo sapiens	Q12959	Y2H	21615688
Intra	MAP2K2	P36507	DLG1	Homo sapiens	Q12959	Anti Bait CoIP	21615688
Intra	MAP2K2	P36507	ARAF	Homo sapiens	P10398	Pull Down	11909642
Intra	MAP2K2	P36507	ARAF	Homo sapiens	P10398	Anti Tag CoIP	31980649
Intra	MAP2K2	P36507	ARAF	Homo sapiens	P10398	Y2H	11909642
Intra	MAP2K2	P36507	ARAF	Homo sapiens	P10398	Anti Tag CoIP	24746704
Intra	MAP2K2	P36507	ARAF	Homo sapiens	P10398	Pull Down	32707033
Intra	MAP2K2	P36507	ARAF	Homo sapiens	P10398	Anti Tag CoIP	35271311
Intra	MAP2K2	P36507	BRAF	Homo sapiens	P15056	Anti Bait CoIP	25600339
Intra	MAP2K2	P36507	BRAF	Homo sapiens	P15056	Pull Down	32707033
Intra	MAP2K2	P36507	BRAF	Homo sapiens	P15056	Anti Tag CoIP	24746704
Intra	MAP2K2	P36507	RAF1	Homo sapiens	P04049	Anti Tag CoIP	31980649
Intra	MAP2K2	P36507	RAF1	Homo sapiens	P04049	Y2H	11909642
Intra	MAP2K2	P36507	RAF1	Homo sapiens	P04049	Anti Tag CoIP	35271311
Intra	MAP2K2	P36507	RAF1	Homo sapiens	P04049	Anti Tag CoIP	24746704
Intra	MAP2K2	P36507	RAF1	Homo sapiens	P04049	Pull Down	32707033
Intra	MAP2K2	P36507	KSR1	Homo sapiens	Q8IVT5	Anti Tag CoIP	35271311
Intra	MAP2K2	P36507	KSR1	Homo sapiens	Q8IVT5	Anti Tag CoIP	31980649
Intra	MAP2K2	P36507	KSR1	Homo sapiens	Q8IVT5	Pull Down	32707033
Intra	MAP2K2	P36507	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	MAP2K2	P36507	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	MAP2K2	P36507	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	MAP2K2	P36507	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	MAP2K2	P36507	ARAF	Homo sapiens	Q96II5	Validated Y2H	32296183
Intra	MAP2K2	P36507	ARAF	Homo sapiens	Q96II5	Y2H Array	32296183
Intra	MAP2K2	P36507	ARAF	Homo sapiens	Q96II5	MAPPIT	32296183
Intra	MAP2K2	P36507	ARAF	Homo sapiens	Q96II5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP2K2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P74755	MEK2 Protein, Human (Active, sf9, GST)	P36507 (M1-V400)	≥ 80%, as determined by reducing SDS-PAGE.

MAP2K2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83314	MEK2 Antibody (YA3059)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P83314A	MEK2 Antibody (YA3059)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P84283	MEK2 Antibody (YA3980)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84283A	MEK2 Antibody (YA3980)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P85274	MEK2 Antibody (YA4966)	WB; IHC-P; IHC-F; IF-Tissue	Human, Mouse, Rat
HY-P85274A	MEK2 Antibody (YA4966)(PBS only)	WB; IHC-P; IHC-F; IF-Tissue	Human, Mouse, Rat
HY-P85739	MEK2 Antibody (YA5431)	WB	Human, Rat, Mouse
HY-P86143	Phospho-MEK1/2(Ser217/221) Antibody (YA5835)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86457	MEK-1/2 Antibody (YA6149)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

関連疾患

Diseases	Alias
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Pulmonary Valve Disease	Pulmonary Valve Disorder
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Cardiofaciocutaneous Syndrome 4	CFC4 Cardiofaciocutaneous Syndrome, Type 4
Pulmonary Valve Stenosis	Valvular Pulmonary Stenosis Heart Valve Pulmonary Stenosis Valvar Pulmonary Stenosis Valvate Pulmonary Stenosis Pulmonary Stenosis Pulmonary Valve Stricture Pulmonic Valve Stenosis Ps - [Pulmonary Valve Stenosis] Pvs - [Pulmonary Valve Stenosis] Pulmonary Valvular Stricture Pulmonary Valvular Stenosis Pulmonary Valvular Obstruction Pulmonary Valve Obstruction Obstructed Pulmonary Valve
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Pulmonic Stenosis	Congenital Pulmonary Valvar Stenosis Congenital Stenosis Of Pulmonary Valve Valvular Pulmonic Stenosis Pulmonary Valve Stenosis Pulmonary Stenosis Congenital Pulmonary Valve Stricture Congenital Pulmonary Valve Stenosis
Tafro Syndrome	Thrombocytopenia-Anasarca-Fever-Renal Insufficiency-Organomegaly Syndrome
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Anthrax Disease	Anthrax Ragpicker'S Disease Black Baine Malignant Edema Malignant Pustule Siberian Plague Wool Sorter'S Disease Gas Gangrene Cutaneous Anthrax Anthrax Infection Splenic Fever
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Dyschromatosis Universalis Hereditaria	Duh
Pseudo-Turner Syndrome	Noonan Syndrome
Noonan Syndrome And Noonan-Related Syndrome
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Large Congenital Melanocytic Nevus	Giant Pigmented Hairy Nevus Giant Congenital Melanocytic Nevus Gmn Congenital Pigmented Nevus Lcmn Gphn Giant Congenital Nevus Bathing Trunk Nevus Congenital Giant Pigmented Nevus Congenital Hairy Nevus Giant Hairy Nevus Giant Pigmented Nevus Congenital Giant Pigmented Nevus Of Skin Congenital Melanocytic Nevus Syndrome Giant Congenital Melanocytic Nevi Giant Congenital Pigmented Nevus Melanocytic Nevus Syndrome, Congenital
Rhabdomyosarcoma
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Skin Granular Cell Tumor	Granular Cell Neoplasm Of The Skin Granular Cell Tumor Of Skin Granular Cell Tumour Of Skin Skin Granular Cell Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	純度	Rare Diseases
HY-E70844	MAP2K2 Recombinant Human Active Protein Kinase	/	Unkown
HY-RS08036	MAP2K2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08037	Map2k2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08038	Map2k2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	MAP2K2	VGNC	VGNC:102632
Rattus norvegicus	MAP2K2	RGD	RGD:61888
Mus musculus	MAP2K2	MGD	MGI:1346867
Macaca mulatta	MAP2K2	VGNC	VGNC:81453
Bos taurus	MAP2K2	VGNC	VGNC:55215
Canis familiaris	MAP2K2	VGNC	VGNC:110517
Others	MAP2K2	NCBI