country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-182277

Copy Link Print Information

GSK-1264

GSK-1264 is an HIV-1 integrase inhibitor. GSK-1264 binds to a site spanning the HIV-1 integrase catalytic core domain and C-terminal domain, mediates formation of an open polymer of HIV-1 integrase dimers via inhibitor-bridged contacts between adjacent dimers. GSK-1264 disrupts late-stage HIV replication by interfering with viral particle assembly. GSK-1264 stimulates inappropriate polymerization of HIV-1 integrase. GSK-1264 can be used for the research of HIV infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1392118-63-6
分子式: C₂₆H₂₈FNO₅
分子量:453.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

GSK-1264 構造式

CAS 番号: 1392118-63-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HIV アイソフォーム固有の製品をすべて表示 :

体外実験

GSK1264 (100-1000 nM; 96 h) potently disrupts formation of mature HIV-1 particles in chronically infected A1953 cells, significantly reducing the percentage of mature virions and increasing deformed particles^[1].
GSK1264 (0.5-1.0 mM) binds to a bipartite interface formed by the CTD and CCD of adjacent HIV-1 IN^Y15A,D185A dimers, inducing formation of an open polymer structure at 4.4 Å resolution^[1].
GSK1264 (8-10 μM) induces concentration-dependent aggregation of HIV-1 IN fragments containing both CCD and CTD domains in vitro, and this activity requires specific CTD residues at the GSK1264 binding interface^[1].
GSK1264 (7 days) inhibits replication of diverse primary HIV-1 isolates in PBMCs with IC₅₀ values of 2-100 μM, and naturally occurring IN polymorphisms can modulate its potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1392118-63-6
分子量 453.50
分子式 C₂₆H₂₈FNO₅
SMILES

CC(C)(C)O[C@@H](C1=C(C2=CC(F)=C(OCCC3)C3=C2C)C4=CC=CC=C4C(N1C)=O)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Gupta K, et al. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol. 2016;14(12):e1002584. Published 2016 Dec 9. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

GSK-1264

HIV アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

GSK-1264 関連分類

HY-182277 関連分類