1392118-63-6
Chemical Structure
GSK-1264
- CAS No.: 1392118-63-6
- Formula:C26H28FNO5
- Molecular Weight:453.50
InChIKey: LDALHHGVIZRJPA-QHCPKHFHSA-N
SMILES: CC(C)(C)O[C@@H](C1=C(C2=CC(F)=C(OCCC3)C3=C2C)C4=CC=CC=C4C(N1C)=O)C(O)=O
Biological Activity: GSK-1264 is an HIV-1 integrase inhibitor. GSK-1264 binds to a site spanning the HIV-1 integrase catalytic core domain and C-terminal domain, mediates formation of an open polymer of HIV-1 integrase dimers via inhibitor-bridged contacts between adjacent dimers. GSK-1264 disrupts late-stage HIV replication by interfering with viral particle assembly. GSK-1264 stimulates inappropriate polymerization of HIV-1 integrase. GSK-1264 can be used for the research of HIV infection[1].
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GSK-1264 | GSK-1264 is an HIV-1 integrase inhibitor. GSK-1264 binds to a site spanning the HIV-1 integrase catalytic core domain and C-terminal domain, mediates formation of an open polymer of HIV-1 integrase dimers via inhibitor-bridged contacts between adjacent dimers. GSK-1264 disrupts late-stage HIV replication by interfering with viral particle assembly. GSK-1264 stimulates inappropriate polymerization of HIV-1 integrase. GSK-1264 can be used for the research of HIV infection. | |||||||||||||||||||||
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Keywords
