Leteprinim potassium
Based on 1 Customer Validation
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.0%
- CAS 番号: 192564-13-9
- 分子式: C15H12KN5O4
- 分子量:365.39
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Leteprinim (5-50 ng/mL, 24 and 48 h) potassium enhances neurotransmitter release, increases secretion of synaptophysin in PC12 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4]
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Dosage:60 mg/kg
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Administration:IP; single dosage
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Result:The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.
In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.
化学情報
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CAS 番号 192564-13-9
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性状 Solid
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分子量 365.39
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分子式 C15H12KN5O4
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Color White to off-white
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SMILES
O=C(C1=CC=C(C=C1)NC(CCN2C=NC3=C2N=CNC3=O)=O)O[K]
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別名
AIT-082
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. [Content Brief]
[2]. Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93. [Content Brief]
[3]. Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47(2):325-9. [Content Brief]
[4]. Gencpınar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Leteprinim potassium 関連分類
HY-120251A 関連分類
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