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LX7101 monohydrochloride

3 Cited Publications
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Based on 3 publication(s) in Google Scholar

LX7101 monohydrochloride is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.

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  • CAS 番号: 2319882-48-7
  • 分子式: C23H30ClN7O3
  • 分子量:487.98
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • LX7101 monohydrochloride Chemical Structure
    LX7101 monohydrochloride 構造式
  • Experimental Validation Results for LX7101 monohydrochloride
  • Experimental Validation Results for LX7101 monohydrochloride
  • Experimental Validation Results for LX7101 monohydrochloride
CAS 番号: 2319882-48-7
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LIM Kinase (LIMK) アイソフォーム固有の製品をすべて表示

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ROCK アイソフォーム固有の製品をすべて表示

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PKA アイソフォーム固有の製品をすべて表示

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  • LX7101 monohydrochloride Chemical Structure
    LX7101 monohydrochloride Chemical Structure
    1/16
  • 1/16

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 May;42(18):1478-1491. [Abstract]

    Customer Validation
     Both LX7101 (5 μM) and TH-257 (5 μM) inhibits the colony-forming ability of melanoma cells (A375-MA2, MeWo, and SK-MEL-147 cells) in soft-agar.

  • 1/16

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2023 May;42(18):1478-1491. [Abstract]

    Customer Validation
     Both LX7101 (5 μM; 24 h) and TH-257 (5 μM; 24 h) reduces the phosphorylation of G3BP1 in A375-MA2 and SK-MEL-147 cells.

  • 1/16

    LX7101 monohydrochloride purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Aug 2;8(1):11585. [Abstract]

    Customer Validation
     Western blot analysis of GFAP protein levels in LX7101 and DMSO-treated iNPC-KO lines. GAPDH is used as a loading control.

  • LX7101 monohydrochloride