Mefatinib free base
Based on 1 Customer Validation
Mefatinib free base (Mifanertinib) is an orally active EGFR and HER2 kinase inhibitor with IC50 values of 0.4 nM and 11.7 nM, respectively. Mefatinib free base inhibits tumor growth in mouse models of lung cancer xenografts that overexpress EGFR/HER2, carry EGFR mutations, or carry Erlotinib (HY-50896)-resistant EGFR double mutations. Mefatinib free base can be used for the research of advanced EGFR-mutant non-small cell lung cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.40%
- CAS 番号: 1639014-72-4
- 分子式: C21H19ClF3N5O2
- 分子量:465.86
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Help & FAQs
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EGFR アイソフォーム固有の製品をすべて表示
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生物活性
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EGFR 0.4 nM (IC50) |
HER2 11.7 nM (IC50) |
Mefatinib (0.2 mg/kg) free base achieves 99.6% tumor growth inhibition in a nude mouse xenograft model of human lung adenocarcinoma HCC827[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1639014-72-4
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性状 Solid
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分子量 465.86
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分子式 C21H19ClF3N5O2
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Color White to off-white
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SMILES
O=C(NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1OC(F)F)/C=C/CN(C)C
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別名
Mifanertinib
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 50 mg/mL (107.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1466 mL | 10.7328 mL | 21.4657 mL | 53.6642 mL |
| 5 mM | 0.4293 mL | 2.1466 mL | 4.2931 mL | 10.7328 mL | |
| 10 mM | 0.2147 mL | 1.0733 mL | 2.1466 mL | 5.3664 mL | |
| 15 mM | 0.1431 mL | 0.7155 mL | 1.4310 mL | 3.5776 mL | |
| 20 mM | 0.1073 mL | 0.5366 mL | 1.0733 mL | 2.6832 mL | |
| 25 mM | 0.0859 mL | 0.4293 mL | 0.8586 mL | 2.1466 mL | |
| 30 mM | 0.0716 mL | 0.3578 mL | 0.7155 mL | 1.7888 mL | |
| 40 mM | 0.0537 mL | 0.2683 mL | 0.5366 mL | 1.3416 mL | |
| 50 mM | 0.0429 mL | 0.2147 mL | 0.4293 mL | 1.0733 mL | |
| 60 mM | 0.0358 mL | 0.1789 mL | 0.3578 mL | 0.8944 mL | |
| 80 mM | 0.0268 mL | 0.1342 mL | 0.2683 mL | 0.6708 mL | |
| 100 mM | 0.0215 mL | 0.1073 mL | 0.2147 mL | 0.5366 mL |
Mefatinib free base 関連分類
HY-152852 関連分類
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