Mutated EGFR-IN-1
Based on 1 publication(s) in Google Scholar
Mutated EGFR-IN-1 (Osimertinib analog) (Intermediate 168) is a structural analog of Osimertinib (HY-15772) and can be used as a pharmaceutical intermediate for EGFR inhibitors.
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- 純度: 99.90%
- CAS 番号: 1421372-66-8
- 分子式: C25H31N7O
- 分子量:445.56
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Mutated EGFR-IN-1
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生物活性
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.
EGFR inhibitors specifically block epidermal growth factor receptors, thereby inhibiting tumor proliferation by cutting off growth signals of tumor cells. They can be used to study malignant tumors such as non-small cell lung cancer, pancreatic cancer, and colorectal cancer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1421372-66-8
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性状 Solid
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分子量 445.56
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分子式 C25H31N7O
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Color Pale purple to khaki
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SMILES
NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C
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別名
Osimertinib analog
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : ≥ 75 mg/mL (168.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2444 mL | 11.2218 mL | 22.4437 mL | 56.1092 mL |
| 5 mM | 0.4489 mL | 2.2444 mL | 4.4887 mL | 11.2218 mL | |
| 10 mM | 0.2244 mL | 1.1222 mL | 2.2444 mL | 5.6109 mL | |
| 15 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7406 mL | |
| 20 mM | 0.1122 mL | 0.5611 mL | 1.1222 mL | 2.8055 mL | |
| 25 mM | 0.0898 mL | 0.4489 mL | 0.8977 mL | 2.2444 mL | |
| 30 mM | 0.0748 mL | 0.3741 mL | 0.7481 mL | 1.8703 mL | |
| 40 mM | 0.0561 mL | 0.2805 mL | 0.5611 mL | 1.4027 mL | |
| 50 mM | 0.0449 mL | 0.2244 mL | 0.4489 mL | 1.1222 mL | |
| 60 mM | 0.0374 mL | 0.1870 mL | 0.3741 mL | 0.9352 mL | |
| 80 mM | 0.0281 mL | 0.1403 mL | 0.2805 mL | 0.7014 mL | |
| 100 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5611 mL |
Mutated EGFR-IN-1 関連分類
HY-78869 関連分類
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