Neorauflavane
Based on 1 Customer Validation
Neorauflavane is a tyrosinase inhibitor with mushroom tyrosinase IC50 values of 30 nM and 500 nM, and Ki values of 19 nM and 130 nM. Neorauflavane inhibits monophenolase and diphenolase activities, binds to tyrosinase’s active site via its B-ring resorcinol motif and A-ring methoxy group. Neorauflavane reduces melanin synthesis in melanoma cells. Neorauflavane can be used for the research of skin hyperpigmentation.
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- 純度: 96.0%
- CAS 番号: 53734-74-0
- 分子式: C21H22O5
- 分子量:354.40
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | IC50 |
13 μM
Compound: 3
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Inhibition of alpha-MSH-stimulated melanin production in mouse B16 cells after 72 hrs by microplate reader analysis
Inhibition of alpha-MSH-stimulated melanin production in mouse B16 cells after 72 hrs by microplate reader analysis
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[PMID: 26706112] |
Neorauflavane (Compound 3) (0-140 nM; 10-25 min) potently inhibits the monophenolase activity of mushroom tyrosinase via a competitive, simple reversible slow-binding inhibition mode, with an IC50 of 30 nM and a Ki of 19 nM[1].
Neorauflavane (0-720 μM; 25 min) inhibits the diphenolase activity of mushroom tyrosinase via competitive inhibition, with an IC50 of 500 nM and a Ki of 130 nM[1].
Neorauflavane (0-20 μM; 72 h) reduces α-MSH (HY-P0252)-stimulated melanin content in B16 mouse melanoma cells in a dose-dependent manner, with an IC50 of 13 μM, and shows no cytotoxicity at effective concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 53734-74-0
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性状 Solid
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分子量 354.40
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分子式 C21H22O5
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Color White to off-white
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SMILES
COC1=C2C(OC[C@@H](C3=C(C=C(O)C=C3)O)C2)=CC4=C1C=CC(C)(C)O4
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Neorauflavane 関連分類
HY-N3200 関連分類
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