71 Results for "

solid-phase synthesis

" in MedChemExpress (MCE) Product Catalog:
Products (71)

71 Results for "solid-phase synthesis" in MCE Product Catalog:

1
1 Cited Publications
製品番号: HY-W010712
CAS 番号: 109425-51-6
研究分野:  

Others

Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
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1
1 Cited Publications
製品番号: HY-W013081
CAS 番号: 132327-80-1
Fmoc-Gln(Trt)-OH is a glutamine derivative containing amine protecting group Fmoc. Fmoc-Gln(Trt)-OH can be used in solid-phase peptide synthesis .
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製品番号: HY-Y1703
CAS 番号: 148893-10-1
研究分野:  

Others

HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions .
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製品番号: HY-Y1636
CAS 番号: 154445-77-9
Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
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製品番号: HY-142104
CAS 番号: 934816-82-7
別名: 2-Chlorotrityl Chloride Resin (100-200 mesh,1% DVB,0.4-3.0mmol/g)
Target:  

Drug Intermediate

研究分野:  

Cancer

2-CTC Resin (100-200 mesh,1% DVB,0.4-3.0mmol/g) is a solid-phase synthesis carrier that has been used to study metabolic disorders in prostate cancer cells. 2-CTC Resin (100-200 mesh,1% DVB,0.4-3.0mmol/g) can be used as a reaction solution of terminal residues and adenine nucleotides to form cyclic peptides. 2-CTC Resin (100-200 mesh,1% DVB,0.4-3.0mmol/g) can prevent racemization during the incorporation of the first protected amino acid and minimized diketopiperazine formation. 2-CTC Resin (100-200 mesh,1% DVB,0.4-3.0mmol/g) is one of the most commonly used and versatile resins available for large-scale production of peptides .
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製品番号: HY-W002327
CAS 番号: 132388-59-1
Fmoc-Asn (Trt)-OH is an Fmoc-protected asparagine derivative. Fmoc-Asn (Trt)-OH supports solid-phase peptide synthesis .
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製品番号: HY-41456
CAS 番号: 3849-21-6
Ethyl 2-cyano-2-(hydroxyimino) acetate (Oxyma) is a peptide coupling additive. Ethyl 2-cyano-2-(hydroxyimino) acetate suppresses racemization during peptide coupling and improves the coupling efficiency of both solution-phase and solid-phase peptide synthesis .
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製品番号: HY-Y0912
CAS 番号: 94790-37-1
別名: N-HBTU
研究分野:  

Inflammation/Immunology

HBTU (N-HBTU) is a guanidinium-based peptide coupling reagent and immunological sensitizer. HBTU can be used in combination with bases such as DIPEA (HY-130142) to complete coupling reactions, with HOBt and TMU as by-products. HBTU is a standard reagent in automated solid-phase peptide synthesis, particularly for the Fmoc/tBu strategy, which effectively promotes coupling steps, but it is not suitable for sterically hindered amino acids or dipeptide derivatives. HBTU can induce rhinitis, dermatitis, bronchial asthma and severe allergic reactions. HBTU can be used to study the pathogenesis of allergic reactions, occupational rhinitis, allergic contact dermatitis and bronchial asthma .
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製品番号: HY-W008558
CAS 番号: 103478-62-2
研究分野:  

Others

Fmoc-N-Me-Leu-OH is an N-Fmoc-N-methyl amino acid that can be used in peptide coupling reactions. Fmoc-N-Me-Leu-OH is primarily used as a standard building block in solid-phase peptide synthesis (SPPS) to introduce N-methylleucine residues into peptide chains, thereby enhancing the enzymatic stability, altering conformational flexibility, and modifying the biological activity of the target peptide .
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製品番号: HY-104004
CAS 番号: 120173-57-1
純度:  98.11%
別名: Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH; Fmoc-Ser[GalNAc(Ac)3-α-D]-OH; Fmoc-Ser(Ac3AcNH-α-Gal)-OH
研究分野:  

Cancer

Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH (Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH) is a protected glycosylated amino acid and Tn antigen. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH serves as a building block in the solid-phase synthesis of Tn-based cancer vaccine constructs. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH supports solid-phase peptide synthesis .
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製品番号: HY-W011556
CAS 番号: 94790-35-9
別名: TCFH
N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate (TCFH) is a powerful coupling and derivatizing reagent for ester prodrug synthesis. N,N,N',N'-Tetramethylchloroformamidinium hexafluorophosphate can be used for antitumor drugs before medicine research .
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製品番号: HY-W007655
CAS 番号: 92122-45-7
Fmoc-D-Lys (Boc)-OH is an Fmoc- and Boc-protected D-lysine derivative. Fmoc-D-Lys (Boc)-OH ensures the precise incorporation of D-lysine into peptide chains, maintaining the specific conformation and biological activity of peptides. Fmoc-D-Lys (Boc)-OH can be used in research on the synthesis of peptides containing unnatural amino acids .
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製品番号: HY-W072147
CAS 番号: 82911-78-2
別名: Fmoc-L-Ser-OMe
研究分野:  

Others

Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is an Fmoc-protected L-serine methyl ester and also a solid-phase peptide synthesis intermediate. Fmoc-Ser-OMe is linked to Ellman resin via its hydroxyl side chain. Fmoc-Ser-OMe is used in peptide synthesis .
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製品番号: HY-W008235
CAS 番号: 84000-07-7
研究分野:  

Cancer

Fmoc-N-Me-Ala-OH is an Fmoc-protected N-methyl-L-alanine and also a building block for solid-phase peptide synthesis. As a building block, Fmoc-N-Me-Ala-OH is used to synthesize peptidomimetic antagonists of XIAP BIR3 derived from Smac/DIABLO .
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製品番号: HY-Y0973
CAS 番号: 56602-33-6
BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification .
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製品番号: HY-46317
CAS 番号: 105931-57-5
研究分野:  

Metabolic Disease

DMT-5Me-dC(Bz)-CE Phosphoramidite is a chemical structural unit that can be used in solid-phase DNA synthesis. DMT-5Me-dC(Bz)-CE Phosphoramidite can introduce the 5-methylcytidine base into the DNA chain to enhance its stability and binding affinity. DMT-5Me-dC(Bz)-CE Phosphoramidite can be used to construct modified oligonucleotides, especially for constructing locked nucleic acids (LNA) .
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製品番号: HY-W111226
CAS 番号: 252049-16-4
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .
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製品番号: HY-W024615
CAS 番号: 25055-86-1
別名: 3-(3-Methyl-3H-diazirin-3-yl)propanoic acid
研究分野:  

Others

Me-diazirine-cooh (3-(3-Methyl-3H-diazirin-3-yl) propanoic acid) is a molecular building block containing an aliphatic diazirine ring. Me-diazirine-cooh undergoes orthogonal coupling in solid-phase peptide synthesis to introduce the Diazirine group into collagen-mimetic peptides. Me-diazirine-cooh is used to construct the photoaffinity probe P1 .
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製品番号: HY-111531
CAS 番号: 206055-75-6
純度:  98.75%
DMTr-LNA-5MeU-3-CED-phosphoramidite is a Phosphoramidite derivative and Nucleoside derivative .
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製品番号: HY-P1130
CAS 番号: 908844-75-7
別名: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain) .
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