56602-33-6
Chemical Structure
BOP hexafluorophosphate
- CAS No.: 56602-33-6
- Formula:C12H22F6N6OP2
- Molecular Weight:442.28
IUPAC Name: ((1H-benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)
InChIKey: MGEVGECQZUIPSV-UHFFFAOYSA-N
SMILES: F[P-](F)(F)(F)(F)F.CN(C)[P+](N(C)C)(N(C)C)ON1C2=CC=CC=C2N=N1
Biological Activity: BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BOP hexafluorophosphate | 98% | BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification. | ||||||||||||||||||||
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References
- [1]. Forest M, et al. BOP reagent for the coupling of pGlu and Boc-His(Tos) in solid phase peptide synthesis. Int J Pept Protein Res. 1990;35(2):89-94. [Content Brief]
- [2]. Akula HK, et al. Facile Modifications at the C4 Position of Pyrimidine Nucleosides via In Situ Amide Activation with 1H-Benzotriazol-1-yloxy-tris(dimethyl-amino)phosphonium Hexafluorophosphate. Curr Protoc Nucleic Acid Chem. 2019;76(1):e73. [Content Brief]
