252049-16-4
Chemical Structure
Fmoc-His(3-Me)-OH
- CAS No.: 252049-16-4
- Formula:C22H21N3O4
- Molecular Weight:391.42
IUPAC Name: Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-Np-methyl-L-histidine
InChIKey: UEDYXEZHNPXCFB-FQEVSTJZSA-N
SMILES: O=C(O)[C@H](CC1=CN=CN1C)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O
Biological Activity: Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fmoc-His(3-Me)-OH | 99.67% | Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Tanaka M, et al. His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx. Peptides. 2009;30(8):1502-1507. [Content Brief]
- [2]. Kumrungsee T, et al. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells. Food Chem. 2014;152:218-224. [Content Brief]
- [3]. Arispe N, et al. Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity. Biophys J. 2008;95(10):4879-4889. [Content Brief]
Keywords
