SNIPER(ER)-110
SNIPER(ER)-110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively.
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- CAS 番号: 2241690-03-7
- 分子式: C66H83N5O11
- 分子量:1122.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | DC50 |
<3 nM
Compound: 6; SNIPER(ER)-110
|
Protac activity at ERalpha/XIAP in human MCF7 cells assessed as induction of ERalpha degradation after 4 hrs by Western blot analysis
Protac activity at ERalpha/XIAP in human MCF7 cells assessed as induction of ERalpha degradation after 4 hrs by Western blot analysis
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[PMID: 31047748] |
化学情報
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CAS 番号 2241690-03-7
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分子量 1122.39
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分子式 C66H83N5O11
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SMILES
O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)C[C@@H](OC3=CC=CC(OCCOCCOCCOCC(N(C)CCOC4=CC=C(/C(C5=CC=C(O)C=C5)=C(C6=CC=CC=C6)/CC)C=C4)=O)=C3)C1)N[C@@H]7CCCC8=C7C=CC=C8
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SNIPER(ER)-110 関連分類
HY-122825 関連分類
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