Timolol hemimaleate
Based on 6 publication(s) in Google Scholar
Timolol ((S)-L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topical Timolol hemimaleate is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol hemimaleate can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 33305-95-2
- 分子式: C13H24N4O3S.1/2C4H4O4
- 分子量:374.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Timolol hemimaleate
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生物活性
Timolol hemimaleate can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol hemimaleate can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-month old male Wistar rats[3].
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Dosage:5 mg/kg.
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Administration:Timolol (5 mg/kg daily for 12-week)
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Result:Showed cardioprotective effect.
化学情報
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CAS 番号 33305-95-2
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分子量 374.45
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分子式 C13H24N4O3S.1/2C4H4O4
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SMILES
OC(/C=C\C(O)=O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N2CCOCC2.[1/2]
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別名
(S)-L-714,465 hemimaleate; MK 950 hemimaleate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Mater
Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection. [Abstract]2025 Jan 6:e2419306. PMID: 39763100 -
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Protein Cell
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]2019 Mar;10(3):178-195. PMID: 29542010 -
Redox Biol
2024 Dec 21:79:103481. PMID: 39721495 -
Mater Today Bio
Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas. [Abstract]2025 Apr 12:32:101752. PMID: 40290897 -
純度とドキュメンテーション
参考文献
[1]. James Barnes; Majid Moshirfar. Timolol.
[2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [Content Brief]
[3]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 2014 Oct;46(5):377-87. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Timolol hemimaleate 関連分類
HY-17494B 関連分類
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