Trecovirsen
Based on 1 Customer Validation
Trecovirsen (GEM91) is an antiviral agent targeting HIV gag mRNA, which hybridizes with complementary HIV gag mRNA at the initiation site. Trecovirsen induces a reversible, dose-dependent prolongation of activated partial thromboplastin time via its polyanionic property. Trecovirsen is applicable to research related to HIV infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.98%
- CAS 番号: 153021-75-1
- 分子量:7776.30
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
| Species | Dose | Route | Plasma Concentration | AUC0-t | T1/2 | MRT | Tmax |
|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[2] | 4 mg/kg | i.v. | 41.7 μg/mL | 163 μg·h/mL | 75.4 h | 80 h | 2.13 h |
化学情報
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CAS 番号 153021-75-1
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性状 Solid
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分子量 7776.30
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Color White to off-white
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SMILES
[Trecovirsen]
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別名
GEM91
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 200 mg/mL (25.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2242 KB)
参考文献
[1]. Séréni D, et al. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects. J Clin Pharmacol. 1999;39(1):47-54. [Content Brief]
[2]. Grindel JM, et al. Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion. Antisense Nucleic Acid Drug Dev. 1998;8(1):43-52. [Content Brief]
[3]. Zhang R, et al. Pharmacokinetics and tissue distribution in rats of an oligodeoxynucleotide phosphorothioate (GEM 91) developed as a therapeutic agent for human immunodeficiency virus type-1. Biochem Pharmacol. 1995;49(7):929-939. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.1286 mL | 0.6430 mL | 1.2860 mL | 3.2149 mL |
| 5 mM | 0.0257 mL | 0.1286 mL | 0.2572 mL | 0.6430 mL | |
| 10 mM | 0.0129 mL | 0.0643 mL | 0.1286 mL | 0.3215 mL | |
| 15 mM | 0.0086 mL | 0.0429 mL | 0.0857 mL | 0.2143 mL | |
| 20 mM | 0.0064 mL | 0.0321 mL | 0.0643 mL | 0.1607 mL | |
| 25 mM | 0.0051 mL | 0.0257 mL | 0.0514 mL | 0.1286 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Trecovirsen 関連分類
HY-149906 関連分類
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- Trecovirsen
- 153021-75-1
- GEM91
- GEM 91
- GEM-91
- HIV
- mRNA
- acquired immunodeficiency syndrome
- human immunodeficiency virus type 1 infection
- human peripheral blood lymphocytes
- macrophages
- HIV gag mRNA
- activated partial thromboplastin time
- CEM cells
- cynomolgus monkeys
- rhesus monkeys
- Sprague-Dawley rats
- Inhibitor
- inhibitor
- inhibit