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Cat. No.: HY-148410A

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Zorevunersen sodium

(Synonyms: STK-001 sodium)

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Zorevunersen sodium is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen sodium increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen sodium restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen sodium can be used for research on Dravet syndrome.

For research use only. We do not sell to patients.

Purity: 99.27%
CAS No.: 2415330-05-9
Formula: C₂₃₄H₃₁₇N₇₁Na₁₇O₁₂₄P₁₇S₁₇
Molecular Weight:7197.2 (free acid)

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Zorevunersen sodium Chemical Structure

CAS No.: 2415330-05-9

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Sodium Channel Isoforms :

In Vivo

Zorevunersen (20 μg; intracerebroventricular injection; unilateral single injection; postnatal day 2) sodium prevents seizures in pre-weaning Scn1a^+/- mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

75% C57BL/6:25% 129S6/SvEvTac (Scn1a+/− Dravet Syndrome model)^[1]
Dosage:

20 μg
Administration:

i.c.v.; single unilateral injection; postnatal day 2 (P2)
Result:

Completely prevented seizures in pre-weaning cohort.
Significantly reduced seizure frequency in post-weaning cohort.
Prolonged survival in post-weaning cohort.
Restored PV interneuron intrinsic excitability to vehicle-treated wild-type levels.
Significantly elevated action potential firing frequencies compared to vehicle-treated Scn1a+/− mice .
Failed to rescue reduced AP upstroke velocity of vehicle-treated Scn1a+/− PV interneurons.
Caused no significant difference in seizure frequency compared to vehicle-treated WT mice in wild-type cohort.
Significantly reduced PV interneuron excitability relative to vehicle-treated WT mice in wild-type cohort.

Chemical Information

CAS No. 2415330-05-9
Appearance Solid
Molecular Weight 7197.2 (free acid)
Formula C₂₃₄H₃₁₇N₇₁Na₁₇O₁₂₄P₁₇S₁₇
Color White to off-white
SMILES

[Zorevunersen (sodium)]
Synonyms

STK-001 sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 20 mg/mL

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

References

[1]. Wengert ER, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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