Zorevunersen
Based on 1 Customer Validation
Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome.
For research use only. We do not sell to patients.
- Purity: 98.50%
- CAS No.: 2415330-04-8
- Formula: C204H263N63O114P20S20
- Molecular Weight:7197.20
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:75% C57BL/6:25% 129S6/SvEvTac (Scn1a+/− Dravet Syndrome model)[1]
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Dosage:20 μg
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Administration:i.c.v.; single unilateral injection; postnatal day 2 (P2)
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Result:Completely prevented seizures in pre-weaning cohort.
Significantly reduced seizure frequency in post-weaning cohort.
Prolonged survival in post-weaning cohort.
Restored PV interneuron intrinsic excitability to vehicle-treated wild-type levels.
Significantly elevated action potential firing frequencies compared to vehicle-treated Scn1a+/− mice .
Failed to rescue reduced AP upstroke velocity of vehicle-treated Scn1a+/− PV interneurons.
Caused no significant difference in seizure frequency compared to vehicle-treated WT mice in wild-type cohort.
Significantly reduced PV interneuron excitability relative to vehicle-treated WT mice in wild-type cohort.
Chemical Information
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CAS No. 2415330-04-8
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Appearance Solid
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Molecular Weight 7197.20
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Formula C204H263N63O114P20S20
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Color White to off-white
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SMILES
[Zorevunersen]
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Synonyms
STK-001
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2242 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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