2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Zorevunersen

Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Zorevunersen sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

RNA, (P-thio)[2′-O-(2-methoxyethyl)](A-G-m5U-m5U-G-G-A-G-m5C-A-A-G-A-m5U-m5U-A-m5U-m5C)

Zorevunersen Chemical Structure

CAS No. : 2415330-04-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Zorevunersen:

Zorevunersen Related Antibodies

Top Publications Citing Use of Products

View All Sodium Channel Isoform Specific Products:

View All Isoforms
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome[1].

IC50 & Target

Nav1.1

 

In Vivo

Zorevunersen (20 μg; intracerebroventricular injection; unilateral single injection; postnatal day 2) prevents seizures in pre-weaning Scn1a+/- mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 75% C57BL/6:25% 129S6/SvEvTac (Scn1a+/− Dravet Syndrome model)[1]
Dosage: 20 μg
Administration: i.c.v.; single unilateral injection; postnatal day 2 (P2)
Result: Completely prevented seizures in pre-weaning cohort.
Significantly reduced seizure frequency in post-weaning cohort.
Prolonged survival in post-weaning cohort.
Restored PV interneuron intrinsic excitability to vehicle-treated wild-type levels.
Significantly elevated action potential firing frequencies compared to vehicle-treated Scn1a+/− mice .
Failed to rescue reduced AP upstroke velocity of vehicle-treated Scn1a+/− PV interneurons.
Caused no significant difference in seizure frequency compared to vehicle-treated WT mice in wild-type cohort.
Significantly reduced PV interneuron excitability relative to vehicle-treated WT mice in wild-type cohort.
Molecular Weight

7197.20

Formula

C204H263N63O114P20S20
CAS No.
SMILES

[Zorevunersen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Zorevunersen Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zorevunersen2415330-04-8STK-001STK001STK 001Sodium ChannelNa channelsNa+ channelswild-type miceScn1a geneScn1a+/? Dravet Syndrome miceNaV1.1 proteinparvalbumin-positive inhibitory interneuronsScn1a mRNA transcriptsPV interneuronDravet SyndromeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Zorevunersen
Cat. No.:
HY-148410
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.