NEK6 - NIMA related kinase 6 Gene

Also Known as SID6-1512

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10783

About NEK6

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,257,606-124,353,307 (from NCBI)

This gene has 15 transcripts (splice variants), 180 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a kinase required for progression through the metaphase portion of Mitosis. Inhibition of the encoded protein can lead to Apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NEK6 Products (7)

mRNA Protein Name
NM_001145001.3 NP_001138473.1 serine/threonine-protein kinase Nek6 isoform 1
NM_001166167.2 NP_001159639.1 serine/threonine-protein kinase Nek6 isoform 3
NM_001166168.2 NP_001159640.1 serine/threonine-protein kinase Nek6 isoform 2
NM_001166169.2 NP_001159641.1 serine/threonine-protein kinase Nek6 isoform 4
NM_001166170.2 NP_001159642.1 serine/threonine-protein kinase Nek6 isoform 2
NM_001166171.2 NP_001159643.1 serine/threonine-protein kinase Nek6 isoform 1
NM_014397.6 NP_055212.2 serine/threonine-protein kinase Nek6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
14563848 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20873783 GOA
enables kinesin binding IPI
IPI: Inferred from physical interaction
19001501 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14563848 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16476580 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19001501 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
11516946 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
20873783 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
20873783 GOA
Biological Process GO Annotation Evidence References Source
involved in chromosome segregation IDA
IDA: Inferred from direct assay
14563848 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
19001501 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
14563848 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12840024 GOA
involved in regulation of mitotic metaphase/anaphase transition IDA
IDA: Inferred from direct assay
14563848 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with centrosome IDA
IDA: Inferred from direct assay
20873783 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12054534 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12054534 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK6 Protein Structure

Pkinase

Pkinase: Protein kinase domain (45 - 298)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek6

  • NIMA (never in mitosis gene a)-related kinase 6

NEK6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEK6 Q9HC98 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
NEK6 Q9HC98 TASOR2 Homo sapiens Q5VWN6-2
Y2H Prey Pooling
25416956
Intra
NEK6 Q9HC98 TASOR2 Homo sapiens Q5VWN6-2
Y2H Array
25416956
Intra
NEK6 Q9HC98 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
NEK6 Q9HC98 NEK9 Homo sapiens Q8TD19
Pull Down
32707033
Intra
NEK6 Q9HC98 NEK9 Homo sapiens Q8TD19
Anti Bait CoIP
17353931
Intra
NEK6 Q9HC98 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
33961781
Intra
NEK6 Q9HC98 NEK9 Homo sapiens Q8TD19
Anti Tag CoIP
28514442
Intra
NEK6 Q9HC98 XIAP Homo sapiens P98170
Y2H Array
31515488
Intra
NEK6 Q9HC98 XIAP Homo sapiens P98170
Validated Y2H
25416956
Intra
NEK6 Q9HC98 TNK2 Homo sapiens Q07912
Y2H Prey Pooling
25416956
Intra
NEK6 Q9HC98 PIN1 Homo sapiens Q13526
IF
16476580
Intra
NEK6 Q9HC98 PIN1 Homo sapiens Q13526
Anti Tag CoIP
16476580
Intra
NEK6 Q9HC98 PIN1 Homo sapiens Q13526
Pull Down
16476580
Intra
NEK6 Q9HC98 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
NEK6 Q9HC98 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
NEK6 Q9HC98 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
NEK6 Q9HC98 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
NEK6 Q9HC98 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
NEK6 Q9HC98 HSD17B14 Homo sapiens Q9BPX1
Y2H Prey Pooling
25416956
Intra
NEK6 Q9HC98 HSD17B14 Homo sapiens Q9BPX1
Y2H Array
25416956
Intra
NEK6 Q9HC98 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
NEK6 Q9HC98 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra
NEK6 Q9HC98 IKZF1 Homo sapiens Q13422
Y2H Array
25416956
Intra
NEK6 Q9HC98 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra
NEK6 Q9HC98 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
NEK6 Q9HC98 IKZF3 Homo sapiens Q9UKT9
Y2H Array
25416956
Intra
NEK6 Q9HC98 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
NEK6 Q9HC98 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Intra
NEK6 Q9HC98 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
NEK6 Q9HC98 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
NEK6 Q9HC98 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

NEK6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82651 NEK6 Antibody (YA2396) WB, IP Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122639 ZINC05007751 99.33% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NEK6 VGNC VGNC:75311
Bos taurus NEK6 VGNC VGNC:31997
Felis catus NEK6 VGNC VGNC:68459
Canis familiaris NEK6 VGNC VGNC:43733
Mus musculus NEK6 MGD MGI:1891638
Rattus norvegicus NEK6 RGD RGD:727779
Others NEK6 NCBI