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NME4 - NME/NM23 nucleoside diphosphate kinase 4 Gene

Also Known as NDPK-D; NM23H4; nm23-H4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4833

About NME4

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:396,729-400,754 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 37.4), fat (RPKM 31.4) and 25 other tissues.

Summary

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous Enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The Enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

NME4 Products (7)

mRNA	Protein	Name
NM_001286433.2	NP_001273362.1	nucleoside diphosphate kinase, mitochondrial isoform b
NM_001286435.2	NP_001273364.1	nucleoside diphosphate kinase, mitochondrial isoform c
NM_001286436.2	NP_001273365.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286438.2	NP_001273367.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286439.2	NP_001273368.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286440.2	NP_001273369.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_005009.3	NP_005000.1	nucleoside diphosphate kinase, mitochondrial isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cardiolipin binding	IDA IDA: Inferred from direct assay	23150663	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lipid transport	IDA IDA: Inferred from direct assay	23150663	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	23150663	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NME4 Protein Structure

NDK

0
100
187 a.a.

Protein Preferred Names	Protein Names
nucleoside diphosphate kinase, mitochondrial	NDK

NME4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NME4	O00746	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
Intra	NME4	O00746	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	NME4	O00746	CABP5	Homo sapiens	Q9NP86	Validated Y2H	32296183
Intra	NME4	O00746	POLR1C	Homo sapiens	O15160	Validated Y2H	32296183
Intra	NME4	O00746	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	NME4	O00746	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	NME4	O00746	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	NME4	O00746	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	NME4	O00746	TRAPPC2	Homo sapiens	P0DI81-3	Validated Y2H	32296183
Intra	NME4	O00746	CABP2	Homo sapiens	Q9NPB3	Validated Y2H	32296183
Intra	NME4	O00746	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	NME4	O00746	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	NME4	O00746	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	NME4	O00746	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	NME4	O00746	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	NME4	O00746	LMO4	Homo sapiens	P61968	Validated Y2H	32296183
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	NME4	O00746	TRIP13	Homo sapiens	Q15645	Validated Y2H	32296183
Intra	NME4	O00746	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	NME4	O00746	CIB1	Homo sapiens	Q99828	Y2H Array	32296183
Intra	NME4	O00746	CIB1	Homo sapiens	Q99828	Validated Y2H	32296183
Intra	NME4	O00746	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	NME4	O00746	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	NME4	O00746	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	NME4	O00746	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	NME4	O00746	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	NME4	O00746	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	NME4	O00746	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	NME4	O00746	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	NME4	O00746	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	NME4	O00746	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
Intra	NME4	O00746	UBL5	Homo sapiens	Q9BZL1	Validated Y2H	32296183
Intra	NME4	O00746	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	NME4	O00746	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	NME4	O00746	HSF2BP	Homo sapiens	O75031	Validated Y2H	32296183
Intra	NME4	O00746	ZBTB16	Homo sapiens	Q05516	Validated Y2H	32296183
Intra	NME4	O00746	NME2	Homo sapiens	P22392	Anti Tag CoIP	27499296
Intra	NME4	O00746	LPL	Homo sapiens	P06858	Validated Y2H	32814053
Intra	NME4	O00746	LPL	Homo sapiens	P06858	Y2H Array	32814053
Intra	NME4	O00746	LPL	Homo sapiens	P06858	Y2H Pooling	32814053
Intra	NME4	O00746	PACSIN1	Homo sapiens	Q9BY11	Y2H Pooling	32814053
Intra	NME4	O00746	PACSIN1	Homo sapiens	Q9BY11	Validated Y2H	32814053
Intra	NME4	O00746	PACSIN1	Homo sapiens	Q9BY11	Y2H Array	32814053
Intra	NME4	O00746	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	NME4	O00746	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	NME4	O00746	SUFU	Homo sapiens	Q9UMX1	Y2H Prey Pooling	32296183
Intra	NME4	O00746	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Anti Tag CoIP	27499296
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Prey Pooling	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Validated Y2H	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Array	31515488
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Array	32296183
Intra	NME4	O00746	NME1	Homo sapiens	P15531	Y2H Prey Pooling	25416956
Intra	NME4	O00746	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	NME4	O00746	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	NME4	O00746	MLH1	Homo sapiens	P40692	Validated Y2H	32296183
Intra	NME4	O00746	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	NME4	O00746	CDKN2D	Homo sapiens	P55273	Validated Y2H	32296183
Intra	NME4	O00746	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	32296183
Intra	NME4	O00746	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	NME4	O00746	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	NME4	O00746	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	NME4	O00746	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	NME4	O00746	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183
Intra	NME4	O00746	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	NME4	O00746	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	NME4	O00746	SNCA	Homo sapiens	P37840	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

NME4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83722	NME4 Antibody(YA3454)	WB, IHC-P	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09375	NME4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NME4	VGNC	VGNC:75358
Rattus norvegicus	NME4	RGD	RGD:1591334
Mus musculus	NME4	MGD	MGI:1931148
Others	NME4	NCBI