2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. NME4 Antibody(YA3454)

NME4 Antibody(YA3454) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NME4.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

NME4 Antibody(YA3454) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NME4.
Host

Mouse
Clonality

Monoclonal
Molecular Weight
Predicted band size: 21 kDa;
Observed band size: 21 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Full length human recombinant protein of human NME4 produced in 293T cell.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
Purity Affinity Purified Conjugation Non-conjugated
Modification Unmodified Isotype IgG2b
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:17028143, PubMed:18635542, PubMed:23150663)
Subcellular Localization：Mitochondrion intermembrane space; Peripheral membrane protein; Mitochondrion matrix
Expression：
Tissue_specificity:Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes
Isoforms & Post-Translational Modification：O00746 has 2 isomers: O00746-1: 20659 Da (predicted); O00746-2: 12979 Da (predicted).
Subunit：Homohexamer (PubMed:10799505). Interacts with OPA1 (PubMed:23150663). Interacts with CAPN8 (By similarity)
Database

Entrez Gene: 4833 Human

SwissProt: O00746 Human

OMIM: 601818 Human

Research Field

Signal Transduction
Synonyms
NDPK-D; nm23-H4; NM23H4
Documentation
User Guide for Antibodies (1077 KB)
References

NME4 Antibody(YA3454) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NME4 Antibody(YA3454)
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HY-P83722
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