NME4 Antibody(YA3454)
(Synonyms: NDPK-D; nm23-H4; NM23H4)NME4 Antibody(YA3454) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NME4.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
NME4 Antibody(YA3454) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to NME4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 21 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 21 kDa
Full length human recombinant protein of human NME4 produced in 293T cell.
Affinity Purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NME4 is a Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration. Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria. In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling[1][2][3][4][5].
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Subcellular Localization
Mitochondrion intermembrane space; Peripheral membrane protein; Mitochondrion matrix
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Expression
Tissue_specificity:Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes -
Isoforms & Post-Translational Modification
O00746 has 2 isomers: O00746-1: 20659 Da (predicted); O00746-2: 12979 Da (predicted).
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Subunit
Homohexamer (PubMed:10799505). Interacts with OPA1 (PubMed:23150663). Interacts with CAPN8 (By similarity)
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SwissProt ID
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Synonyms
NDPK-D; nm23-H4; NM23H4
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Research Field
Signal Transduction
Documentation
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