Mycosporine 2 glycine
Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 149092-45-5
- Formula: C12H18N2O7
- Molecular Weight:302.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mycosporine 2 glycine (0.1-10 μM; 20 h) exhibits excellent biocompatibility with RAW 264.7 murine macrophages, with no decrease in cell viability[1].
Mycosporine 2 glycine (0.1-10 μM; 1 h pretreatment) potently inhibits LPS (HY-D1056)-induced NO production and the expression of key inflammatory genes iNOS and COX-2 in RAW 264.7 mouse macrophages[1].
Mycosporine 2 glycine (5-10 μM; 1 h pretreatment) inhibits the H2O2-induced upregulated expression of antioxidant genes Sod1, Cat and Nrf2, as well as the increased enzymatic activities of SOD and CAT, in RAW 264.7 mouse macrophages[1].
Mycosporine 2 glycine binds tightly to human TYRP1 with high binding affinity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 murine macrophage cells
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Concentration:0.1, 1, 5, 10 μM
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Incubation Time:20 h
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Result:Showed no reduction in cell viability, with viability values of 100.3%, 105.1%, 106.1%, and 110.1% relative to untreated controls (100%).
Significantly increased cell viability at 5 μM and 10 μM compared to controls.
Caused no visible morphological changes between untreated and treated cells.
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Cell Line:H2O2-stressed RAW 264.7 murine macrophage cells
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Concentration:5, 10 μM
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Incubation Time:1 h pretreatment prior to H2O2 exposure
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Result:Suppressed H2O2-induced upregulation of Sod1, Cat, and Nrf2 mRNA at both 5 μM and 10 μM, with significant reductions observed for all three genes.
Chemical Information
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CAS No. 149092-45-5
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Molecular Weight 302.28
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Formula C12H18N2O7
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SMILES
COC1=C(NCC(O)=O)C[C@@](O)(CO)C/C1=N\CC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tarasuntisuk S, et al. Mycosporine-2-glycine exerts anti-inflammatory and antioxidant effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Arch Biochem Biophys. 2019;662:33-39. [Content Brief]
[2]. Amin N, et al. Mycosporine-Like Amino Acids as a Potential Inhibitor of Tyrosinase-Related Protein 1: Computational Screening, Pharmacokinetics, and Molecular Dynamics Simulation. Mol Biotechnol. 2025;67(4):1674-1694. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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