4-Pyridoxic acid
Based on 1 Customer Validation
4-Pyridoxic acid is an endogenous substrate of renal organic anion transporters (OAT1/3) and a catabolite of vitamin B6. 4-Pyridoxic acid is excreted through OAT1/3-mediated tubular active secretion, which can reflect OAT1/3 activity. Elevated plasma concentrations of 4-Pyridoxic acid are associated with decreased OAT1/3 activity in chronic kidney disease (CKD) and can be used as a biomarker to reflect the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS).
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- Purity: 99.82%
- CAS No.: 82-82-6
- 화학식: C8H9NO4
- 분자량:183.16
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 82-82-6
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Appearance Solid
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분자량 183.16
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화학식 C8H9NO4
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Color Light yellow to light brown
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SMILES
O=C(C1=C(O)C(C)=NC=C1CO)O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
1 M NaOH : ≥ 100 mg/mL (545.97 mM)
DMSO : 5 mg/mL (27.30 mM; ultrasonic and adjust pH to 8 with NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.5 mg/mL (2.73 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Yoshimura N, et al. Urinary 4-pyridoxic acid as a non-invasive biomarker for evaluating osteoarthritis severity: findings from the ROAD study. Aging Clin Exp Res. 2025 Feb 25;37(1):50. [Content Brief]
[2]. Sullivan DW Jr, et al. A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats. Hum Exp Toxicol. 2017 Jul;36(7):718-726. [Content Brief]
[3]. Tan SPF, et al. Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease. Clin Pharmacol Ther. 2023 Dec;114(6):1243-1253. [Content Brief]
[4]. Sharma SK, et al. Determination of vitamin B6 vitamers and pyridoxic acid in biological samples. J Chromatogr. 1992 Jul 1;578(1):45-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO / 1 M NaOH | 1 mM | 5.4597 mL | 27.2985 mL | 54.5971 mL | 136.4927 mL |
| DMSO / 1 M NaOH | 5 mM | 1.0919 mL | 5.4597 mL | 10.9194 mL | 27.2985 mL |
| 10 mM | 0.5460 mL | 2.7299 mL | 5.4597 mL | 13.6493 mL | |
| 15 mM | 0.3640 mL | 1.8199 mL | 3.6398 mL | 9.0995 mL | |
| 20 mM | 0.2730 mL | 1.3649 mL | 2.7299 mL | 6.8246 mL | |
| 25 mM | 0.2184 mL | 1.0919 mL | 2.1839 mL | 5.4597 mL | |
| 1 M NaOH | 30 mM | 0.1820 mL | 0.9100 mL | 1.8199 mL | 4.5498 mL |
| 40 mM | 0.1365 mL | 0.6825 mL | 1.3649 mL | 3.4123 mL | |
| 50 mM | 0.1092 mL | 0.5460 mL | 1.0919 mL | 2.7299 mL | |
| 60 mM | 0.0910 mL | 0.4550 mL | 0.9100 mL | 2.2749 mL | |
| 80 mM | 0.0682 mL | 0.3412 mL | 0.6825 mL | 1.7062 mL | |
| 100 mM | 0.0546 mL | 0.2730 mL | 0.5460 mL | 1.3649 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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