82-82-6
Chemical Structure
4-Pyridoxic acid
- CAS No.: 82-82-6
- Formula:C8H9NO4
- Molecular Weight:183.16
IUPAC Name: 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinic acid
InChIKey: HXACOUQIXZGNBF-UHFFFAOYSA-N
SMILES: O=C(C1=C(O)C(C)=NC=C1CO)O
Biological Activity: 4-Pyridoxic acid is an endogenous substrate of renal organic anion transporters (OAT1/3) and a catabolite of vitamin B6. 4-Pyridoxic acid is excreted through OAT1/3-mediated tubular active secretion, which can reflect OAT1/3 activity. Elevated plasma concentrations of 4-Pyridoxic acid are associated with decreased OAT1/3 activity in chronic kidney disease (CKD) and can be used as a biomarker to reflect the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS)[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Pyridoxic acid | 99.82% | 4-Pyridoxic acid is an endogenous substrate of renal organic anion transporters (OAT1/3) and a catabolite of vitamin B6. 4-Pyridoxic acid is excreted through OAT1/3-mediated tubular active secretion, which can reflect OAT1/3 activity. Elevated plasma concentrations of 4-Pyridoxic acid are associated with decreased OAT1/3 activity in chronic kidney disease (CKD) and can be used as a biomarker to reflect the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS). | ||||||||||||||||||||
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4-Pyridoxic acid (Standard) | 98.11% | 4-Pyridoxic acid (Standard) is the analytical standard of 4-Pyridoxic acid. This product is intended for research and analytical applications. 4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine. | ||||||||||||||||||||
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4-Pyridoxic acid-d3 | 98.79% | 4-Pyridoxic acid-d3 is the deuterium labeled 4-Pyridoxic acid. 4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine. | ||||||||||||||||||||
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References
- [1]. Yoshimura N, et al. Urinary 4-pyridoxic acid as a non-invasive biomarker for evaluating osteoarthritis severity: findings from the ROAD study. Aging Clin Exp Res. 2025 Feb 25;37(1):50. [Content Brief]
- [2]. Sullivan DW Jr, et al. A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats. Hum Exp Toxicol. 2017 Jul;36(7):718-726. [Content Brief]
- [3]. Tan SPF, et al. Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease. Clin Pharmacol Ther. 2023 Dec;114(6):1243-1253. [Content Brief]
- [4]. Sharma SK, et al. Determination of vitamin B6 vitamers and pyridoxic acid in biological samples. J Chromatogr. 1992 Jul 1;578(1):45-51. [Content Brief]
