SGD-1882
Based on 1 Customer Validation
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 95.29%
- CAS No.: 1222490-34-7
- 화학식: C42H39N5O7
- 분자량:725.79
-
보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
Biological Activity
SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1222490-34-7
-
Appearance Solid
-
분자량 725.79
-
화학식 C42H39N5O7
-
Color Light yellow to yellow
-
SMILES
O=C(C1=CC(OC)=C(OCCCOC(C=C(N=C[C@@]2([H])N(C=C(C3=CC=C(N)C=C3)C2)C4=O)C4=C5)=C5OC)C=C1N=C6)N7[C@@]6([H])CC(C8=CC=C(OC)C=C8)=C7
-
Synonyms
PBD dimer
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (137.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (269 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3778 mL | 6.8890 mL | 13.7781 mL | 34.4452 mL |
| 5 mM | 0.2756 mL | 1.3778 mL | 2.7556 mL | 6.8890 mL | |
| 10 mM | 0.1378 mL | 0.6889 mL | 1.3778 mL | 3.4445 mL | |
| 15 mM | 0.0919 mL | 0.4593 mL | 0.9185 mL | 2.2963 mL | |
| 20 mM | 0.0689 mL | 0.3445 mL | 0.6889 mL | 1.7223 mL | |
| 25 mM | 0.0551 mL | 0.2756 mL | 0.5511 mL | 1.3778 mL | |
| 30 mM | 0.0459 mL | 0.2296 mL | 0.4593 mL | 1.1482 mL | |
| 40 mM | 0.0344 mL | 0.1722 mL | 0.3445 mL | 0.8611 mL | |
| 50 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6889 mL | |
| 60 mM | 0.0230 mL | 0.1148 mL | 0.2296 mL | 0.5741 mL | |
| 80 mM | 0.0172 mL | 0.0861 mL | 0.1722 mL | 0.4306 mL | |
| 100 mM | 0.0138 mL | 0.0689 mL | 0.1378 mL | 0.3445 mL |
SGD-1882 Related Classifications
HY-101127 Related Classifications
Powered by Bioz