Antiproliferative agent-3
Antiproliferative agent-3 is an antiproliferative agent. Antiproliferative agent-3 exhibits anticancer activity against a variety of cancers, including estrogen receptor-positive breast cancer. Antiproliferative agent-3 shows no toxicity to wild-type zebrafish embryos. Antiproliferative agent-3 can be used in the research of chronic myeloid leukemia, promyelocytic leukemia, Burkitt's lymphoma, estrogen receptor-positive mammary adenocarcinoma, cervical cancer, and lung cancer.
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- 화학식: C11H12N2O5S
- 분자량:284.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Antiproliferative agent-3 (Compound 4) (72 h) potently inhibits the growth of multiple human tumour cell lines, with exceptional activity against MCF-7 cells (IC50 = 0.00019 μM), and shows no toxicity to MRC-5 normal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type[1]
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Dosage:1 µM, 2.5 µM, 5 µM, 10 µM, 25 µM, 50 µM, 100 µM, 125 µM
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Administration:in embryo water; continuous; 6 hpf to 120 hpf
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Result:Allowed all embryos to survive at all tested concentrations up to 125 µM, with no teratogenic malformations.
Resulted in an embryo heartbeat rate of 154 beats per minute at 125 µM, compared to 158 beats per minute in the control group, with no pericardial edema observed.
Determined a lethal concentration 50 (LC50) to be >125 µM.
Chemical Information
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분자량 284.29
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화학식 C11H12N2O5S
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SMILES
NC(C1=CSC(C[C@H]2O[C@@H]3CC(O[C@@H]3[C@H]2O)=O)=N1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-3 Related Classifications
HY-145866 Related Classifications
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- Antiproliferative agent-3
- Antiproliferative agent3
- Antiproliferative agent 3
- Drug Intermediate
- T cell leukaemia
- lung carcinoma
- oestrogen receptor positive breast adenocarcinoma
- chronic myeloid leukaemia
- promyelocytic leukaemia
- estrogen receptor positive breast adenocarcinoma cells
- MCF-7 cells
- cervix carcinoma
- zebrafish models
- Burkitt’s lymphoma
- Inhibitor
- inhibitor
- inhibit