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Cat. No.: HY-184729

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Antitumor agent-223

Antitumor agent-223 is an anticancer agent and TRK inhibitor. Antitumor agent-223 exerts potent antitumor activity against liver cancer and breast cancer. Antitumor agent-223 can be used for the research of hepatocellular carcinoma and breast cancer.

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CAS No.: 3124621-78-6
화학식: C₂₄H₂₂F₄N₄O
분자량:458.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antitumor agent-223 Chemical Structure

CAS No.: 3124621-78-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Trk Receptor Isoforms :

In Vitro

Antitumor agent-223 (Compound IIIc) potently inhibits the proliferation of HepG2 hepatocellular carcinoma cells (IC₅₀ = 2.06 μM) and MCF-7 breast cancer cells (IC₅₀ = 3.15 μM)^[1].
Antitumor agent-223 (1-7 μM; 48-96 h) effectively inhibits the migration of HepG2 hepatocellular carcinoma cells in a concentration- and time-dependent manner, with a migration rate of 16.70% after treatment at 7 μM for 96 h^[1].
Antitumor agent-223 (1-5 μM) potently reduces the colony-forming ability of HepG2 hepatocellular carcinoma cells, with a colony formation rate of 12.50% at 5 μM and 38.20% at 3 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

HepG2 hepatocellular carcinoma cells
Concentration:

1-5 μM (48 h, 96 h); 7 μM (96 h)
Incubation Time:

48 h, 96 h
Result:

Inhibits HepG2 cell migration in a concentration- and time-dependent manner.
Reduces the cell migration rate to 16.70% at 7 μM for 96 h (compared to the control group's 70.08%, P < 0.01).
Reduces migration rates relative to controls at 1 μM, 3 μM, and 5 μM at both 48 h and 96 h.

Chemical Information

CAS No. 3124621-78-6
분자량 458.45
화학식 C₂₄H₂₂F₄N₄O
SMILES

O=C(N1)/C(C2=C1C=CC(NCC3=C(F)C=CC(C(F)(F)F)=C3)=C2)=C\C4=CN=C(CCCC)N4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Design, synthesis, and anti-tumor evaluation of indolin-2-one derivatives based on 3D-QSAR. Bioorganic & medicinal chemistry letters. 2026 Jul;136:130618. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Antitumor agent-223

All Trk Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antitumor agent-223 Related Classifications

HY-184729 Related Classifications