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Cat. No.: HY-144334

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CHIKV-IN-3

CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC₅₀ values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC₅₀>100 μM). Prophylactic effect.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2906132-49-6
화학식: C₂₄H₃₀ClNO
분자량:383.95

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

CHIKV-IN-3 Chemical Structure

CAS No.: 2906132-49-6

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

EC₅₀: 1.55 µM (CHIKV-122508); 0.14 µM (CHIKV-6708)^[1]

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	CC₅₀	>100 μM Compound: (E)-42	Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability	[PMID: 35085859]

In Vitro

CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 μM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC₅₀ of 1.55 μM and demonstrates low cytotoxicity (CC₅₀=129.6 μM)^[1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 μM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa CCL2 cells, HeLa CCL2 cells infected with CHIKV-122508
Concentration:

0.1-100 µM
Incubation Time:

24 hours
Result:

Inhibited the CHIKV replication with an EC₅₀ of 1.55 µM and demonstrated low cytotoxicity(CC₅₀=129.6 µM)

Chemical Information

CAS No. 2906132-49-6
분자량 383.95
화학식 C₂₄H₃₀ClNO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tran QTN, et al. Discovery and development of labdane-oxindole hybrids as small-molecule inhibitors against chikungunya virus infection. Eur J Med Chem. 2022; 230:114110. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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CHIKV-IN-3

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CHIKV-IN-3 Related Classifications

HY-144334 Related Classifications