Chlorfortunone A
Chlorfortunone A is a novel sesquiterpenoid dimers, can be isolated from the roots of Chloranthus fortunei. Chlorfortunone A inhibits transforming growth factor (TGF)-β activity.
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- 화학식: C31H38O5
- 분자량:490.63
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Chlorfortunone A (compound 1) (10-40 μM; 4 h) downregulates TGF-β-induced Smad2 phosphorylation (A) and the expression of vimentin (B) in MDA-MB-231 cells[1].
Chlorfortunone A (25 μM; 48 h) significantly downregulated the expression of vimentin, a Smad-regulated EMT-marker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:10, 20, 40 μM
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Incubation Time:4 hours; accompanied with 10 ng/mL TGF-β1 for 30 min
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Result:Significantly downregulated the TGF-β-induced p-Smad2 expression in a concentration-dependent manner without any impact on the expression of Smad2/3 protein.
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Cell Line:MDA-MB-231 cells
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Concentration:25 μM
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Incubation Time:48 hours
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Result:Significantly downregulated the expression of vimentin.
Chemical Information
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분자량 490.63
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화학식 C31H38O5
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SMILES
C[C@@]1([C@@H]2C[C@@H]2C(CC3)=C1[C@]([C@]3(C=C4)C=C[C@@]4([C@@H](C(C)C)C5)[C@@H](C5=O)C)([H])/C6=C(C)/C(OC)=O)[C@@H](O)C6=O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chlorfortunone A Related Classifications
HY-N10577 Related Classifications
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