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Clorgyline

(Synonyms: M&B 9302)
8 Cited Publications
고객리뷰

Based on 8 publication(s) in Google Scholar

Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases.

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  • Purity: 99.76%
  • CAS No.: 17780-72-2
  • 화학식: C13H15Cl2NO
  • 분자량:272.17
  • 보관:
    Pure form   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Clorgyline Chemical Structure
    Clorgyline Chemical Structure
  • Experimental Validation Results for Clorgyline
  • Experimental Validation Results for Clorgyline
  • Experimental Validation Results for Clorgyline
  • Experimental Validation Results for Clorgyline
  • Experimental Validation Results for Clorgyline
  • Experimental Validation Results for Clorgyline
  • Experimental Validation Results for Clorgyline
CAS No.: 17780-72-2
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Publications Citing Use of MedChemExpress (MCE) Clorgyline

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In Vivo Efficacy StudyCell Imaging/StainingCell Migration/Invasion AssayFlow CytometryBio/Physico-chemical AssayApoptosis AnalysisELISA
  • In Vivo Efficacy Study
  • Flow Cytometry
  • ELISA
  • Cell Imaging/Staining
  • Bio/Physico-chemical Assay
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All Monoamine Oxidase Isoforms

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  • Clorgyline Chemical Structure
    Clorgyline Chemical Structure
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    Clorgyline purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2025 Mar 22;13(3):e010555. [Abstract]

    Customer Validation
     Tumor growth curves of mice in different treatment groups. The findings demonstrated that the tumor growth rate in the Clorgyline hydrochloride (Clo; 15 mg/kg; i.p.; three times weekly for 7 doses) group was significantly reduced compared with the control group.

  • 1/16

    Clorgyline purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2025 Mar 22;13(3):e010555. [Abstract]

    Customer Validation
     Clorgyline hydrochloride (Clo; 15 mg/kg; i.p.; three times weekly for 7 doses). FACS analysis of the proportion of CD8+CD45+ T cells in tumor tissues from different treatment groups, showing a marked increase in the proportion of CD8+CD45+ T cells in the treatment group.

  • 1/16

    Clorgyline purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2025 Mar 22;13(3):e010555. [Abstract]

    Customer Validation
     Clorgyline hydrochloride (Clo; 15 mg/kg; i.p.; three times weekly for 7 doses). ELISA experiments to detect the content of IFN-γ in tumor tissues from different treatment groups.

  • 1/16

    Clorgyline purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2023 Dec 15:904:166688. [Abstract]

    Customer Validation
     Levels of ROS in cells treated with 0.1 % DMSO and 33 μM TPhP or co-treated with 20 μM of the MAOA inhibitor Clorgyline (Clorgyline hydrochloride, CGL) and 33 μM TPhP for 48 h. The results showed that the MAOA inhibitor Clorgyline can reduced ROS levels.

  • 1/16

    Clorgyline purchased from MedChemExpress. Usage Cited in: Sci Total Environ. 2023 Dec 15:904:166688. [Abstract]

    Customer Validation
     Levels of GSH, MDA, and SOD in cells treated with 0.1 % DMSO and 33 μM TPhP or co-treated with 20 μM of the MAOA inhibitor Clorgyline (Clorgyline hydrochloride, CGL) and 33 μM TPhP for 48 h. These parameters that represent oxidative stress would back to normal by the MAOA inhibitor, Clorgyline.

  • 1/16

    Clorgyline purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 13;41(11):111827. [Abstract]

    Customer Validation
     Clorgyline hydrochloride (1 μM). Cancer-related metabolic inhibitors and RSK inhibitor treatment effect on cancer cell invasion. Cell invasion assay of A549 cells treated with fmk and inhibitors targeting cancer-inducing metabolic enzymes. Cells were pretreated with mitomycin C (10 μg/mL) for 2 h followed by fmk (5 μM) and/or metabolic inhibitor treatment in Matrigel-coated transwell chambers for 24 h to assess invasive potential.

  • 1/16

    Clorgyline purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Dec 13;41(11):111827. [Abstract]

    Customer Validation
     Clorgyline hydrochloride (1 μM). Cancer-related metabolic inhibitors and RSK inhibitor treatment effect on cancer cell anoikis induction. Anoikisassay of A549 cells treated with fmk and inhibitors targeting cancer-inducing metabolic enzymes. Cells were seeded on 1% agarose-treated plates and treated with the inhibitors for 48 h, and detachment-induced cell death was assessed by annexin V staining.

  • Clorgyline