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Cat. No.: HY-161862

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COX-2-IN-44

COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC₅₀ values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity.

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화학식: C₂₇H₂₄ClN₃O
분자량:441.95

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

COX-2-IN-44 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC₅₀ values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity^[1].

IC₅₀ & Target^[1]

COX-2

0.18 μM (IC₅₀)

COX-1

1.14 μM (IC₅₀)

All COX Isoforms :

In Vivo

COX-2-IN-44 (compound 6b) (10 mg/kg; p.o.) shows anti-inflammatory activity in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Twenty-five adult albino Wistar rats (paw edema)^[1]
Dosage:

10 mg/kg
Administration:

P.o.
Result:

Showed anti-inflammatory activity and caused a decrease in paw volume over time and scored a percentage edema of 61.62 %, 54.34 %, and 44.64 % at the 1st, 2nd, and 3rd hour, respectively, decreased the PGE2 plasma level by 42.6 %, reduced the level of IL-1β by 32.0 %.

Chemical Information

분자량 441.95
화학식 C₂₇H₂₄ClN₃O
SMILES

CC(C=C1)=CC=C1NC(C(CC2=CC=C(Cl)C=C2)=C3)=NN=C3/C=C/C4=CC=C(OC)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ewieda SY, et al. Synthesis, COX-2 inhibition, anti-inflammatory activity, molecular docking, and histopathological studies of new pyridazine derivatives. Bioorg Chem. 2024 Sep;150:107623. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

COX-2-IN-44

All COX Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

COX-2-IN-44 Related Classifications

HY-161862 Related Classifications