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Cat. No.: HY-118081

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inS3-54-A26

inS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC₅₀ of 4.0 μM for non-cancerous lung fibroblasts.

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CAS No.: 328998-77-2
화학식: C₂₅H₁₉ClN₂O₂
분자량:414.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

inS3-54-A26 Chemical Structure

CAS No.: 328998-77-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

inS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC₅₀ of 4.0 μM for non-cancerous lung fibroblasts^[1].

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1299	IC₅₀	3.4 μM Compound: A26	Cytotoxicity against human H1299 cells assessed as inhibition of cell survival after 72 hrs by SRB method Cytotoxicity against human H1299 cells assessed as inhibition of cell survival after 72 hrs by SRB method	[PMID: 30145375]

Chemical Information

CAS No. 328998-77-2
분자량 414.88
화학식 C₂₅H₁₉ClN₂O₂
SMILES

CC(NC1=CC=C(C=C1)N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C=C4)Cl)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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inS3-54-A26

High-Throughput Bioactive Compound Library

All STAT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

inS3-54-A26 Related Classifications

HY-118081 Related Classifications