KRAS-IN-54
KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer.
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- CAS No.: 3084918-70-4
- 화학식: C60H78F5N11O7S
- 분자량:1192.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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KRas G12D |
KRAS G13D |
KRAS-IN-54 (compound 3) inhibits the viability of AGS (KRASG12D) cells with an IC50 of 10 nM; it also inhibits the viability of HCT-116 (KRASG13D) cells with an IC50 of 27 nM[1].
KRAS-IN-54 inhibits ERK phosphorylation in AGS (KRASG12D) cells with an IC50 of 9 nM; it also inhibits ERK phosphorylation in HCT-116 (KRASG13D) cells with an IC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3084918-70-4
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분자량 1192.39
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화학식 C60H78F5N11O7S
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SMILES
CO[C@H](C1=[C@@](C=C(C=N1)N2CCN(CC2)C)[C@@]3=C4CC(C)(COC([C@@H]5CCCN(C([C@H](CC6=NC(C7=CC4=C(N3CC(F)(F)F)C=C7F)=CS6)NC([C@@H](N(C(C8(F)CCN(C([C@H]9N(C)[C@@H]9C%10CC%10)=O)CC8)=O)C)C%11CCCC%11)=O)=O)N5)=O)C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS-IN-54 Related Classifications
HY-181704 Related Classifications
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