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Cat. No.: HY-N2307B

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(R)-Lirinidine

(Synonyms: (-)-Lirinidine)

(R)-Lirinidine ((-)-Lirinidine) is an aporphine-type alkaloid found in the flower buds and leaves of Nelumbo nucifera. (R)-Lirinidineand inhibits melanogenesis with an IC₅₀ of 19.3 μM. (R)-Lirinidine exerts cytotoxic effects at 100 μM.

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CAS No.: 37082-15-8
화학식: C₁₈H₁₉NO₂
분자량:281.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(R)-Lirinidine Chemical Structure

CAS No.: 37082-15-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

제품 설명

All Melanocortin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B16-4A5	IC₅₀	19.3 μM Compound: 7, 5-demethylnuciferine	Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry Inhibition of melanogenesis in mouse B16-4A5 cells after 72 hrs by spectrophotometry	[PMID: 23270663]

In Vitro

(R)-Lirinidine (Compound 7) (3-100 μM; 72 h) potently inhibits melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells with an IC₅₀ of 19.3 μM, and exhibits cytotoxicity at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 37082-15-8
분자량 281.35
화학식 C₁₈H₁₉NO₂
SMILES

OC1=C(OC)C=C2CCN(C)[C@]3([H])CC4=CC=CC=C4C1=C23
Synonyms

(-)-Lirinidine
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nakamura S, et al. Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells. Bioorg Med Chem. 2013;21(3):779-787. [Content Brief]

Calculators

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
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(R)-Lirinidine

All Melanocortin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(R)-Lirinidine Related Classifications

HY-N2307B Related Classifications