country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-145454B

Copy Link Print Information

(Rac)-Preclamol

(Synonyms: (±)-3-PPP)

(Rac)-Preclamol ((±)-3-PPP) is the racemate of (R)-Preclamol (HY-145454A) and Preclamol (HY-145454A). (Rac)-Preclamol exhibits autoreceptor agonistic activity at dopamine Dopamine Receptor, with almost no effect on postsynaptic dopamine receptors. (Rac)-Preclamol inhibits spontaneous motor activity and the γ-butyrolactone-induced increase in mature striatal Tyrosine Hydroxylase activity. (Rac)-Preclamol can be used in research related to neurological diseases.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 75240-91-4
화학식: C₁₄H₂₁NO
분자량:219.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Preclamol Chemical Structure

CAS No.: 75240-91-4

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Dopamine Receptor Isoforms :

In Vivo

(Rac)-Preclamol ((±)-3-PPP) (0.1-10 mg/kg; s.c.; single dose; 45 minutes prior to sacrifice (biochemical experiments)) dose-dependently reduces spontaneous locomotor activity and inhibits GBL-induced striatal DOPA accumulation in 28-day-old rats, with no significant effects on locomotion or striatal DOPA accumulation in rats younger than 14 days old^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (ages 1, 4, 7, 14, and 28 days)^[1]
Dosage:

0.1 mg/kg; 1 mg/kg; 10 mg/kg; 10 mg/kg
Administration:

s.c.; single dose; 45 minutes prior to sacrifice
Result:

Reduced 28-day-old rats’ spontaneous locomotor activity in a 0.1-10 mg/kg dose-dependent manner and cut activity to ~30% of control at 10 mg/kg, while exerted no locomotor effects on 1/4/7/14-day-old rats.
Lowered GBL-induced striatal DOPA accumulation from 1618 ng/g to 1127 ng/g in 28-day-old rats at 10 mg/kg and caused only trivial non-significant reduction in 4-day-old rats, without changing striatal and whole-brain DA, NA, DOPAC levels in either age group.

Chemical Information

CAS No. 75240-91-4
분자량 219.33
화학식 C₁₄H₂₁NO
SMILES

OC1=CC=CC(=C1)C2CN(CCC)CCC2
Synonyms

(±)-3-PPP
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Hedner T, et al. Development of dopamine autoreceptors in the postnatal rat brain. Journal of neural transmission. 1985;62(1-2):53-63. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

(Rac)-Preclamol

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(Rac)-Preclamol Related Classifications

HY-145454B Related Classifications