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Cat. No.: HY-153504

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TACE-IN-1

TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research.

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CAS No.: 1219812-22-2
화학식: C₂₆H₂₆N₄O₇
분자량:506.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TACE-IN-1 Chemical Structure

CAS No.: 1219812-22-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All TNF Receptor Isoforms :

In Vitro

TACE-IN-1 (1 h pre-incubation; 3.5 h post-LPS addition) inhibits TNF-α production in human whole blood with an IC₅₀ of 281 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	AUC
Rat^[1]	10 mg/kg	p.o.	74 %	13.1 μM·h
Monkey^[1]	3 mg/kg	p.o.	92 %	/
Dog^[1]	3 mg/kg	p.o.	72 %	/
Rat^[1]	100 mg/kg	p.o.	/	210 μM·h
Rat^[1]	300 mg/kg	p.o.	/	780 μM·h
Rat^[1]	500 mg/kg	p.o.	/	1450 μM·h

Chemical Information

CAS No. 1219812-22-2
분자량 506.52
화학식 C₂₆H₂₆N₄O₇
SMILES

C([C@@]1(C(=O)N(COC(C(C)(C)C)=O)C(=O)N1)C2=CC=3C(O2)=CC=CN3)N4C(=O)C=5C(C4)=CC=C(OC)C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Tong L, et al. Development of a prodrug of hydantoin based TACE inhibitor. Bioorg Med Chem Lett. 2017;27(16):3704-3708. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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TACE-IN-1

All TNF Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TACE-IN-1 Related Classifications

HY-153504 Related Classifications