Tetradehydropodophyllotoxin
Based on 1 Customer Validation
Tetradehydropodophyllotoxin possesses antifungal activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.63%
- CAS No.: 42123-27-3
- 화학식: C22H18O8
- 분자량:410.37
-
보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | ED50 |
>20 μg/mL
Compound: 3
|
Cytotoxicity against human A431 cells
Cytotoxicity against human A431 cells
|
[PMID: 8277312] |
| A549 | IC50 |
106.7 μM
Compound: 6'b
|
Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay
|
10.1007/s00044-011-9937-1 |
| BC1 cell line | ED50 |
15.2 μg/mL
Compound: 3
|
Cytotoxicity against human BC1 cells
Cytotoxicity against human BC1 cells
|
[PMID: 8277312] |
| Col2 | ED50 |
8.9 μg/mL
Compound: 3
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 8277312] |
| HEK293 | IC50 |
240 μM
Compound: 6'b
|
Cytotoxicity against Homo sapiens (human) HEK293 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HEK293 cells after 72 hr by MTT assay
|
10.1007/s00044-011-9937-1 |
| HeLa | IC50 |
8.28 μM
Compound: 10
|
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
|
[PMID: 21570846] |
| HT | ED50 |
9.7 μg/mL
Compound: 3
|
Cytotoxicity against human HT cells
Cytotoxicity against human HT cells
|
[PMID: 8277312] |
| KB | ED50 |
4 μg/mL
Compound: 4
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 2849640] |
| KB | ED50 |
5 μg/mL
Compound: 3
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 8277312] |
| KB | IC50 |
29.1 μM
Compound: 6'b
|
Cytotoxicity against Homo sapiens (human) KB cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) KB cells after 72 hr by MTT assay
|
10.1007/s00044-011-9937-1 |
| KB | IC50 |
9.79 μM
Compound: 10
|
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
|
[PMID: 21570846] |
| KB-V1 | ED50 |
13 μg/mL
Compound: 3
|
Cytotoxicity against human KBV1 cells
Cytotoxicity against human KBV1 cells
|
[PMID: 8277312] |
| LNCaP | ED50 |
11.7 μg/mL
Compound: 3
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 8277312] |
| Lu1 | ED50 |
10.6 μg/mL
Compound: 3
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 8277312] |
| P388 | ED50 |
>5 μg/mL
Compound: 3
|
Cytotoxicity in mouse P388 cells
Cytotoxicity in mouse P388 cells
|
[PMID: 8277312] |
| SW480 | IC50 |
>100 μM
Compound: 6'b
|
Cytotoxicity against Homo sapiens (human) SW480 cells after 72 hr by MTT assay
Cytotoxicity against Homo sapiens (human) SW480 cells after 72 hr by MTT assay
|
10.1007/s00044-011-9937-1 |
| U-373MG ATCC | ED50 |
>20 μg/mL
Compound: 3
|
Cytotoxicity against human U373 cells
Cytotoxicity against human U373 cells
|
[PMID: 8277312] |
| ZR-75-1 | ED50 |
>20 μg/mL
Compound: 3
|
Cytotoxicity against human ZR-75-1 cells
Cytotoxicity against human ZR-75-1 cells
|
[PMID: 8277312] |
Chemical Information
-
CAS No. 42123-27-3
-
Appearance Solid
-
분자량 410.37
-
화학식 C22H18O8
-
Color White to off-white
-
SMILES
O=C1OCC2=C(C3=C(C(C4=CC(OC)=C(C(OC)=C4)OC)=C12)C=C5OCOC5=C3)O
-
Synonyms
Dehydropodophyllotoxin
-
Structure Classification
-
Initial Source
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 10 mg/mL (24.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4368 mL | 12.1841 mL | 24.3683 mL | 60.9206 mL |
| 5 mM | 0.4874 mL | 2.4368 mL | 4.8737 mL | 12.1841 mL | |
| 10 mM | 0.2437 mL | 1.2184 mL | 2.4368 mL | 6.0921 mL | |
| 15 mM | 0.1625 mL | 0.8123 mL | 1.6246 mL | 4.0614 mL | |
| 20 mM | 0.1218 mL | 0.6092 mL | 1.2184 mL | 3.0460 mL |