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Cat. No.: HY-157514

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Thalidomide 4'-ether-PEG1-azide

Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs.

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CAS No.: 2758432-02-7
화학식: C₁₇H₁₇N₅O₆
분자량:387.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Thalidomide 4'-ether-PEG1-azide Chemical Structure

CAS No.: 2758432-02-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2758432-02-7
분자량 387.35
화학식 C₁₇H₁₇N₅O₆
SMILES

[N-]=[N+]=NCCOCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen P, et al. α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship. Bioorg Chem. 2021 Nov;116:105295. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Thalidomide 4'-ether-PEG1-azide

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Thalidomide 4'-ether-PEG1-azide

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Thalidomide 4'-ether-PEG1-azide Related Classifications

HY-157514 Related Classifications