Tomuzotuximab
Based on 1 Customer Validation
Tomuzotuximab (Anti-Human EGFR Recombinant Antibody) is a fully human glycoengineered IgG1 monoclonal antibody against EGFR. Tomuzotuximab has anticancer effects.
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- Purity: ≥99.0%
- CAS No.: 1646321-00-7
- 분자량:145.46 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
More
Biological Activity
Human IgG1 kappa
Human
ERBB1/EGFR/HER1
Tomuzotuximab has a fully human glycosylation pattern and is glyco-optimised at its Fc domain, while fully retaining the affinity, specificity, EGFR inhibition and induction of apoptosis of Cetuximab[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized EGFR Protein, Human (621a.a, HEK293, His, HY-P70613) can bind Tomuzotuximab. The EC50 for this effect is 4.29 ng/mL. -
Flow Cytometry analysis of Hela cells labelling ERBB1 (red) with Tomuzotuximab (HY-P99324). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 1646321-00-7
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Appearance Liquid
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분자량 145.46 kDa
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Color Colorless to light yellow
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SMILES
[Tomuzotuximab]
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Synonyms
Anti-Human EGFR Recombinant Antibody; CetuxiMab-GEX, GEXMab52201
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)