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Cat. No.: HY-164349

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WZ-2-033

WZ-2-033 is a potent STAT3 inhibitor. WZ-2-033 inhibits MDA-MB-231, HCC70, and MDA-MB231-4175 cells proliferation, colony survival, migration, and invasion with IC₅₀s of 0.7, 1.3, and 1.3 μM, respectively.

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CAS No.: 2416196-47-7
화학식: C₂₅H₁₈F₃N₃O₄S
분자량:513.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

WZ-2-033 Chemical Structure

CAS No.: 2416196-47-7

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.4 μM Compound: 50	Antiproliferative activity against human A549 cells Antiproliferative activity against human A549 cells	[PMID: 34000483]
MDA-MB-231	IC₅₀	0.7 μM Compound: 50	Antiproliferative activity against human MDA-MB-231 cells Antiproliferative activity against human MDA-MB-231 cells	[PMID: 34000483]
MGC-803	IC₅₀	0.4 μM Compound: 50	Antiproliferative activity against human MGC-803 cells Antiproliferative activity against human MGC-803 cells	[PMID: 34000483]

Chemical Information

CAS No. 2416196-47-7
분자량 513.49
화학식 C₂₅H₁₈F₃N₃O₄S
SMILES

O=C(CC1=C(C2=CC=C(C(F)(F)F)C=C2)N=C3C=C(C=CN31)OC)NC4=CC5=C(C=CS(=O)5=O)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhong Y, et al. The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts. Acta Pharmacol Sin. 2022 Apr;43(4):1013-1023. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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WZ-2-033

All STAT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

WZ-2-033 Related Classifications

HY-164349 Related Classifications