LSD1-IN-10

Cat. No.: HY-136878: Data Sheet Handling Instructions
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LSD1-IN-10 is a LSD1/MAO inhibitor with LSD1 IC₅₀ of 5 nM, MAO-A IC₅₀ of 16 μM, and MAO-B IC₅₀ of 7.4 μM. LSD1-IN-10 suppresses enzymatic activity of LSD1, MAO-A, and MAO-B. LSD1-IN-10 can be used for the research of cancer, alzheimer's disease, parkinson's disease, huntington's disease.

For research use only. We do not sell to patients.

LSD1-IN-10 Chemical Structure

CAS No. : 1235864-15-9

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

LSD1

5 nM (IC₅₀)

MAO-A

16 μM (IC₅₀)

MAO-B

7.4 μM (IC₅₀)

In Vitro

LSD1-IN-10 (Compound 76) potently inhibits LSD1 with an IC₅₀ of 0.005 μM, and is far less potent against MAO-A (IC₅₀ 16 μM) and MAO-B (IC₅₀ 7.4 μM) in cell-free enzymatic assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

295.38

Formula

C₁₉H₂₁NO₂

CAS No.

1235864-15-9

SMILES

N(C(C)C=1C=C2C(=CC1)OCCO2)[C@H]3[C@@H](C3)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nathalie G, et al. Phenylcyclopropylamine derivatives and their medical use. United States, WO2010084160 A. 2010-07-29.

LSD1-IN-10 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-101235864-15-9Histone DemethylaseMonoamine OxidaseMAOMonoamine Oxidase Bneurodegenerative diseasesparkinson's diseaseMonoamine Oxidase Alewy body dementiacanceralzheimer's diseasehuntington's diseaseLysine Specific Demethylase-1Inhibitorinhibitorinhibit

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