ICA-105574
Based on 1 publication(s) in Google Scholar
ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently.
For research use only. We do not sell to patients.
- Purity: 99.25%
- CAS No.: 316146-57-3
- Formula: C19H14N2O4
- Molecular Weight:334.33
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) ICA-105574
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Biological Activity
ICA-105574 (1 μM) reverses the inhibition of peak repolarizing currrents by Dofetilide (HY-B0232) and Moxifloxacin (HY-66011A) to the controlled levels in guinea-pig ventricular myocytes [2]. ICA-105574 (3-10 μM) induces concentration-dependent shortening of APD in guinea-pig ventricular myocytes[2]. ICA-105574 (3 μM) completely reverses the APD prolongation when combined with NS1643 (HY-16916) (10 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 316146-57-3
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Appearance Solid
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Molecular Weight 334.33
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Formula C19H14N2O4
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Color Off-white to light yellow
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SMILES
O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
Kcnq (Kv7) channels exhibit frequency-dependent responses via partial inductor-like gating dynamics. [Abstract]2025 Jun 5;8(1):866. PMID: 40473867
Solvent & Solubility
DMSO : 250 mg/mL (747.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
[1]. Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol. 2010;77(1):58-68. [Content Brief]
[2]. Meng, J., et al., (2013). Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization. European journal of pharmacology, 718(1-3), 87–97. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9911 mL | 14.9553 mL | 29.9106 mL | 74.7764 mL |
| 5 mM | 0.5982 mL | 2.9911 mL | 5.9821 mL | 14.9553 mL | |
| 10 mM | 0.2991 mL | 1.4955 mL | 2.9911 mL | 7.4776 mL | |
| 15 mM | 0.1994 mL | 0.9970 mL | 1.9940 mL | 4.9851 mL | |
| 20 mM | 0.1496 mL | 0.7478 mL | 1.4955 mL | 3.7388 mL | |
| 25 mM | 0.1196 mL | 0.5982 mL | 1.1964 mL | 2.9911 mL | |
| 30 mM | 0.0997 mL | 0.4985 mL | 0.9970 mL | 2.4925 mL | |
| 40 mM | 0.0748 mL | 0.3739 mL | 0.7478 mL | 1.8694 mL | |
| 50 mM | 0.0598 mL | 0.2991 mL | 0.5982 mL | 1.4955 mL | |
| 60 mM | 0.0499 mL | 0.2493 mL | 0.4985 mL | 1.2463 mL | |
| 80 mM | 0.0374 mL | 0.1869 mL | 0.3739 mL | 0.9347 mL | |
| 100 mM | 0.0299 mL | 0.1496 mL | 0.2991 mL | 0.7478 mL |
ICA-105574 Related Classifications
HY-124702 Related Classifications
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