316146-57-3
Chemical Structure
ICA-105574
- CAS No.: 316146-57-3
- Formula:C19H14N2O4
- Molecular Weight:334.33
IUPAC Name: 3-nitro-N-(4-phenoxyphenyl)benzamide
InChIKey: GDWKBKTVROCPNZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3
Biological Activity: ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently[1][2].
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ICA-105574 | 99.25% | ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 can prevent arrhythmias induced by cardiac delayed repolarization. ICA-105574 shortens action potential duration in ventricular myocytes concentration-dependently. | ||||||||||||||||||||
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- [1]. Gerlach AC, et al. Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol. 2010;77(1):58-68. [Content Brief]
- [2]. Meng, J., et al., (2013). Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization. European journal of pharmacology, 718(1-3), 87–97. [Content Brief]
Keywords
