1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ICA-105574

ICA-105574 

Cat. No.: HY-124702
Handling Instructions

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2.

For research use only. We do not sell to patients.

ICA-105574 Chemical Structure

ICA-105574 Chemical Structure

CAS No. : 316146-57-3

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Description

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].

Molecular Weight

334.33

Formula

C19H14N2O4

CAS No.
SMILES

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ICA-105574
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HY-124702
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