KRAS-IN-54
KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer.
For research use only. We do not sell to patients.
- CAS No.: 3084918-70-4
- Formula: C60H78F5N11O7S
- Molecular Weight:1192.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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KRas G12D |
KRAS G13D |
KRAS-IN-54 (compound 3) inhibits the viability of AGS (KRASG12D) cells with an IC50 of 10 nM; it also inhibits the viability of HCT-116 (KRASG13D) cells with an IC50 of 27 nM[1].
KRAS-IN-54 inhibits ERK phosphorylation in AGS (KRASG12D) cells with an IC50 of 9 nM; it also inhibits ERK phosphorylation in HCT-116 (KRASG13D) cells with an IC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3084918-70-4
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Molecular Weight 1192.39
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Formula C60H78F5N11O7S
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SMILES
CO[C@H](C1=[C@@](C=C(C=N1)N2CCN(CC2)C)[C@@]3=C4CC(C)(COC([C@@H]5CCCN(C([C@H](CC6=NC(C7=CC4=C(N3CC(F)(F)F)C=C7F)=CS6)NC([C@@H](N(C(C8(F)CCN(C([C@H]9N(C)[C@@H]9C%10CC%10)=O)CC8)=O)C)C%11CCCC%11)=O)=O)N5)=O)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)